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- W2742298288 abstract "Objective: To investigate the effect of angelica keiskei koidz chalcone on the expression of PCNA and BCL-2 in mice hepatocarcinoma cells. Methods: Fifty mice were inoculated with hepatocarcinoma H22 cells and divided into five groups, with 10 mice per group. High, medium and low chalcone groups were given 40, 20, 5mg/kg/d of chalcone by mouth, respectively. The tumor control group was given saline by mouth and the cylophosphamide group was given 20mg/kg cyclophosphamide by intraperitoneal injection every other day. Ten days later all mice were sacrificed. The proliferation activity of hepatocarcinoma cells was determined by methy tetrazoli- um (MTT) assay, and the levels of the proliferating cell nuclear antigen (PCNA) and BCL-2 protein expression were detected by im- munohisto chemistry method. Results: The cell proliferation activity of high dose chalcone group and tumor control group were (0.716± 0.018) and(1.135±0.032). The difference was significant (P0.05). The expression of PCNA and BCL-2 protein in high dose chalcone group were 28.33% and 16.77% respectively, while which of the tumor control group were 72.77% and 65.17%. The differences between two groups were significant (P0.05). Conclusion: Chalcone can reduce the expression of PCNA and BCL-2, and inhibit the proliferative activity of mice hepatocarcinoma cells." @default.
- W2742298288 created "2017-08-17" @default.
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- W2742298288 date "2011-01-01" @default.
- W2742298288 modified "2023-09-28" @default.
- W2742298288 title "Effect of Angelica keiskei Koidz Chalcone on PCNA and BCL-2 Protein Expression of Mice Hepatocarcinoma Cells" @default.
- W2742298288 hasPublicationYear "2011" @default.
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