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- W2742328305 abstract "A non-invasive molecular delivery method using nano/microbubbles (NB) and ultrasound (US) is an attractive technique for gene therapy. This method is able to deliver macromolecules such as plasmid DNA to a tissue specific site non-invasively. In addition, a non-invasive quantification method of gene expression has been studied by monitoring ^<124> accumulation caused by the of Na/I symporter (NIS) gene expression with positron emission tomography (PET). In the present study, we delivered NIS gene into the skeletal muscle of vasculitis and muscular dystrophy mice by using the US/NB method, and succeed in visualizing the ^<124>I accumulation caused by NIS gene expression in the muscle with PET. The combination of the US/NB delivery with NIS/PET visualization will be a valuable methodology in gene therapy." @default.
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- W2742328305 date "2008-01-01" @default.
- W2742328305 modified "2023-10-18" @default.
- W2742328305 title "1613 Visualization of Na/I symporter(NIS) gene expression in mouse skeletal muscle using positron emission tomography(PET)" @default.
- W2742328305 doi "https://doi.org/10.1299/jsmemecjo.2008.2.0_23" @default.
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