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- W2742401134 abstract "Background: The etiology of benign prostatic hyperplasia (BPH) has not been well established. The preferred medical treatment for many men with symptomatic benign prostatic hyperplasia is either an α-adrenergic receptor antagonist (α-blocker), or a 5α-reductase inhibitor. Single nucleotide polymorphism (SNP) is a powerful tool for successful implementation of individualized treatment.Methods: Eighteen SNPs associated with drug efficacy in a Chinese population were genotyped in 790 BPH cases (330 aggressive and 460 non-aggressive BPH cases) and 1008 controls. All BPH patients were treated with α-adrenergic blockers for at least 9 months. We tested the associations between tagging single nucleotide polymorphism and BPH risk/aggressiveness, clinical characteristics at baseline, including the International Prostate Symptom Score (IPSS) and total prostate volume, and changes in clinical characteristics after treatment.Results: There were nine SNPs associated with BPH risk, clinical progression and therapeutic effect. (1) There were nine tSNPs been chosen in CYP3A4, CYP3A5 and RANBP3L genes. (2) The SNP, rs16902947 in RANBP3L at 5p13.2 (p = .01), was significantly associated with BPH. (3) We found two SNPs, rs16902947 in RANBP3L at 5p13.2 (p = .0388) and rs4646437 in CYP3A4 at 7q21.1 (p = .0325), associated with drug effect. (4) Allele “G” for rs16902947 was found to be risk alleles for BPH risk (OR= 2.357, 95%CI 1.01–1.48). The “A” allele of rs4646437 was associated with lower IPSS at baseline (β= −0.4232, p= .03255).Conclusions: rs16902947, rs16902947 and rs4646437 single nucleotide polymorphisms are significantly associated with the clinical characteristics of benign prostatic hyperplasia and the efficacy of benign prostatic hyperplasia treatment." @default.
- W2742401134 created "2017-08-17" @default.
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- W2742401134 date "2017-08-08" @default.
- W2742401134 modified "2023-10-16" @default.
- W2742401134 title "Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the α-adrenergic receptor antagonist" @default.
- W2742401134 cites W1528756433 @default.
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- W2742401134 cites W1945259997 @default.
- W2742401134 cites W1964130227 @default.
- W2742401134 cites W1967565086 @default.
- W2742401134 cites W1968428144 @default.
- W2742401134 cites W1970803489 @default.
- W2742401134 cites W1988910337 @default.
- W2742401134 cites W1990732773 @default.
- W2742401134 cites W1991011333 @default.
- W2742401134 cites W1996950143 @default.
- W2742401134 cites W1998448005 @default.
- W2742401134 cites W2002004951 @default.
- W2742401134 cites W2006457199 @default.
- W2742401134 cites W2006509971 @default.
- W2742401134 cites W2011858610 @default.
- W2742401134 cites W2014132234 @default.
- W2742401134 cites W2021719730 @default.
- W2742401134 cites W2029185782 @default.
- W2742401134 cites W2038988633 @default.
- W2742401134 cites W2069551851 @default.
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- W2742401134 cites W2081223199 @default.
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- W2742401134 cites W2122393586 @default.
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- W2742401134 doi "https://doi.org/10.1080/13685538.2017.1358261" @default.
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