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- W2742411989 abstract "Introduction - ANA negative systemic lupus erythematosus (SLE) is a relatively uncommonentity in childhood but when it occurs is usually associated with significant multi-system involvementespecially renal. Aim - To describe the clinical profile, treatment and outcome of children with ANAnegative SLE.Methodology - 160 children with SLE were being followed up in Pediatric Rheumatologyand Pediatric Nephrology clinic. Out of this, 16 children were diagnosed to have ANA negative SLEwas included in the study. Their clinical, laboratory, treatment and outcome data were collected fromtheir medical records and entered in the proforma and analyzed.Results - Total of 16 children werefollowed up with ANA negative SLE. 13 (82) were girls and 3 (18) were boys. Mean age at diagnosiswas 10.4 years (range 7 to 14 years). ACR classification criteria for SLE were fulfilled by 5 (31)children. 14 (88) had renal involvement. All underwent renal biopsy. Among these, WHO Class IVlupus nephritis (81) was the most common histopathological finding. All the children had received steroids for the treatment of ANA negative SLE. Cyclophosphamide was used in 3 (19), mycophenolate mofetil was used in 4 (25) and hydroxychloroquine was used in 9 (56) children. 8 (50) of the children had attained complete remission, 3 (19) had attained partial remission and 5 (31) had not attained remission at the end of the follow up. None of the children had become ANA positive during the follow up period. 7(44) patients had flares during the follow up and the maximum number of flares in a single patient was 3 episodes.Conclusion - ANA negative SLE is a rare entity in childhood. We found a prevalence of 10 in our SLE children. Renal involvement was predominant manifestation in our series of children. Treatment with steroids showed adequate response in these children. WHO Class IVlupus nephritis (81) was the most common histopathological" @default.
- W2742411989 created "2017-08-17" @default.
- W2742411989 creator A5046817018 @default.
- W2742411989 date "2017-04-13" @default.
- W2742411989 modified "2023-09-26" @default.
- W2742411989 title "PROFILE OF CHILDREN WITH ANA NEGATIVE SLE IN A TERTIARY CARE HOSPITAL INSOUTH INDIA" @default.
- W2742411989 hasPublicationYear "2017" @default.
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