Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742439855> ?p ?o ?g. }
- W2742439855 abstract "Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitude of diverse human diseases. aGPCRs have been suggested to possess mechanosensory properties, though their mechanism of action is fully unknown. Here we show that the Drosophila aGPCR Latrophilin/dCIRL acts in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. This process depends on the length of the extended ectodomain and the tethered agonist of the receptor, but not on its autoproteolysis, a characteristic biochemical feature of the aGPCR family. Intracellularly, dCIRL quenches cAMP levels upon mechanical activation thereby specifically increasing the mechanosensitivity of neurons. These results provide direct evidence that the aGPCR dCIRL acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response." @default.
- W2742439855 created "2017-08-17" @default.
- W2742439855 creator A5001345830 @default.
- W2742439855 creator A5003220340 @default.
- W2742439855 creator A5015030892 @default.
- W2742439855 creator A5017403142 @default.
- W2742439855 creator A5034712041 @default.
- W2742439855 creator A5036704760 @default.
- W2742439855 creator A5042302969 @default.
- W2742439855 creator A5049163700 @default.
- W2742439855 creator A5057973936 @default.
- W2742439855 creator A5058301286 @default.
- W2742439855 creator A5060475590 @default.
- W2742439855 creator A5060522222 @default.
- W2742439855 creator A5062650642 @default.
- W2742439855 creator A5064930927 @default.
- W2742439855 creator A5066726616 @default.
- W2742439855 creator A5081563301 @default.
- W2742439855 date "2017-08-08" @default.
- W2742439855 modified "2023-10-16" @default.
- W2742439855 title "Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons" @default.
- W2742439855 cites W1583577648 @default.
- W2742439855 cites W1835383273 @default.
- W2742439855 cites W1875939621 @default.
- W2742439855 cites W1932592181 @default.
- W2742439855 cites W1966354110 @default.
- W2742439855 cites W1967513025 @default.
- W2742439855 cites W1970684598 @default.
- W2742439855 cites W1971748110 @default.
- W2742439855 cites W1974740818 @default.
- W2742439855 cites W1977223822 @default.
- W2742439855 cites W1977789280 @default.
- W2742439855 cites W1978387124 @default.
- W2742439855 cites W1980022376 @default.
- W2742439855 cites W1980100800 @default.
- W2742439855 cites W1984957160 @default.
- W2742439855 cites W1986892307 @default.
- W2742439855 cites W1995016025 @default.
- W2742439855 cites W1995852110 @default.
- W2742439855 cites W2002708908 @default.
- W2742439855 cites W2010441615 @default.
- W2742439855 cites W2014786857 @default.
- W2742439855 cites W2021218920 @default.
- W2742439855 cites W2022538678 @default.
- W2742439855 cites W2038709562 @default.
- W2742439855 cites W2040631236 @default.
- W2742439855 cites W2043867460 @default.
- W2742439855 cites W2050707832 @default.
- W2742439855 cites W2051561558 @default.
- W2742439855 cites W2051852715 @default.
- W2742439855 cites W2053050328 @default.
- W2742439855 cites W2058173351 @default.
- W2742439855 cites W2058258523 @default.
- W2742439855 cites W2066517842 @default.
- W2742439855 cites W2067056326 @default.
- W2742439855 cites W2073210804 @default.
- W2742439855 cites W2075947666 @default.
- W2742439855 cites W2082569007 @default.
- W2742439855 cites W2091280052 @default.
- W2742439855 cites W2107282780 @default.
- W2742439855 cites W2111689719 @default.
- W2742439855 cites W2111793184 @default.
- W2742439855 cites W2116120324 @default.
- W2742439855 cites W2130955385 @default.
- W2742439855 cites W2140026382 @default.
- W2742439855 cites W2149241780 @default.
- W2742439855 cites W2150633163 @default.
- W2742439855 cites W2154837481 @default.
- W2742439855 cites W2158976454 @default.
- W2742439855 cites W2159319913 @default.
- W2742439855 cites W2159423248 @default.
- W2742439855 cites W2159540848 @default.
- W2742439855 cites W2161007406 @default.
- W2742439855 cites W2166236034 @default.
- W2742439855 cites W2320612980 @default.
- W2742439855 cites W2413335515 @default.
- W2742439855 cites W2498296569 @default.
- W2742439855 cites W2536080392 @default.
- W2742439855 cites W4211168555 @default.
- W2742439855 doi "https://doi.org/10.7554/elife.28360" @default.
- W2742439855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5548486" @default.
- W2742439855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28784204" @default.
- W2742439855 hasPublicationYear "2017" @default.
- W2742439855 type Work @default.
- W2742439855 sameAs 2742439855 @default.
- W2742439855 citedByCount "119" @default.
- W2742439855 countsByYear W27424398552017 @default.
- W2742439855 countsByYear W27424398552018 @default.
- W2742439855 countsByYear W27424398552019 @default.
- W2742439855 countsByYear W27424398552020 @default.
- W2742439855 countsByYear W27424398552021 @default.
- W2742439855 countsByYear W27424398552022 @default.
- W2742439855 countsByYear W27424398552023 @default.
- W2742439855 crossrefType "journal-article" @default.
- W2742439855 hasAuthorship W2742439855A5001345830 @default.
- W2742439855 hasAuthorship W2742439855A5003220340 @default.
- W2742439855 hasAuthorship W2742439855A5015030892 @default.
- W2742439855 hasAuthorship W2742439855A5017403142 @default.
- W2742439855 hasAuthorship W2742439855A5034712041 @default.
- W2742439855 hasAuthorship W2742439855A5036704760 @default.