FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742444091> ?p ?o ?g. }

• W2742444091 endingPage "2291" @default.
• W2742444091 startingPage "2287" @default.
• W2742444091 abstract "Background: Thyroidectomy, radioactive iodine therapy, chemotherapy, or their combination are treatments of choice for thyroid cancers. However, cancer stem cells (CSCs) may become resistant to therapy, and mutations in somatic genes affect radioiodine uptake. This study determined the effect of a phosphoinositide-3-kinase (PI3K) inhibitor on anaplastic thyroid CSCs. Materials and Methods: The magnetic-activated cell sorting assay was used for segregating CD133-positive CSCs from three anaplastic thyroid carcinoma (ATC) cell lines (C643, SW1736, and 8305C). After confirming the cells’ purity by flow cytometry, they were treated with 5, 10, 20, or 25 μM LY294002, a PI3K inhibitor, and then evaluated at 24 and 48 h. The sodium-iodide symporter (NIS) mRNA level was determined using the quantitative real-time polymerase chain reaction. NIS protein expression was evaluated using western blotting. Results: The PI3K inhibitor, at different concentrations and times, increased the NIS mRNA level (1.30-6.17-fold, P < 0.0001). If the NIS mRNA level in LY294002-treated CD133-positive CSCs was increased more than 2-fold, the NIS protein content was detectable. Conclusions: CD133-positive CSCs isolated from ATC cell lines expressed NIS mRNA and protein after PI3K inhibition. Our findings suggest that molecularly targeted CSC therapy may improve the treatment efficacy of aggressive cancers like ATC." @default.
• W2742444091 created "2017-08-17" @default.
• W2742444091 creator A5049454080 @default.
• W2742444091 creator A5049882423 @default.
• W2742444091 creator A5057534597 @default.
• W2742444091 creator A5059169025 @default.
• W2742444091 creator A5079593433 @default.
• W2742444091 creator A5080500381 @default.
• W2742444091 date "2017-08-27" @default.
• W2742444091 modified "2023-09-23" @default.
• W2742444091 title "Effects of a Phosphoinositide-3-Kinase Inhibitor on Anaplastic Thyroid Cancer Stem Cells" @default.
• W2742444091 cites W1605218581 @default.
• W2742444091 cites W1858247054 @default.
• W2742444091 cites W1974546266 @default.
• W2742444091 cites W1990226334 @default.
• W2742444091 cites W1992819841 @default.
• W2742444091 cites W2002896591 @default.
• W2742444091 cites W2009861669 @default.
• W2742444091 cites W2009906157 @default.
• W2742444091 cites W2031200496 @default.
• W2742444091 cites W2031446155 @default.
• W2742444091 cites W2050170878 @default.
• W2742444091 cites W2083077596 @default.
• W2742444091 cites W2107277218 @default.
• W2742444091 cites W2108232614 @default.
• W2742444091 cites W2109556977 @default.
• W2742444091 cites W2127029182 @default.
• W2742444091 cites W2135340303 @default.
• W2742444091 cites W2143552375 @default.
• W2742444091 cites W2192080449 @default.
• W2742444091 cites W2254230224 @default.
• W2742444091 cites W2321643587 @default.
• W2742444091 cites W2345578064 @default.
• W2742444091 cites W2396331137 @default.
• W2742444091 cites W2509039608 @default.
• W2742444091 cites W2513361464 @default.
• W2742444091 cites W2517222155 @default.
• W2742444091 cites W2525047674 @default.
• W2742444091 cites W2625082907 @default.
• W2742444091 doi "https://doi.org/10.22034/apjcp.2017.18.8.2287" @default.
• W2742444091 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5697493" @default.
• W2742444091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28843268" @default.
• W2742444091 hasPublicationYear "2017" @default.
• W2742444091 type Work @default.
• W2742444091 sameAs 2742444091 @default.
• W2742444091 citedByCount "2" @default.
• W2742444091 countsByYear W27424440912019 @default.
• W2742444091 crossrefType "journal-article" @default.
• W2742444091 hasAuthorship W2742444091A5049454080 @default.
• W2742444091 hasAuthorship W2742444091A5049882423 @default.
• W2742444091 hasAuthorship W2742444091A5057534597 @default.
• W2742444091 hasAuthorship W2742444091A5059169025 @default.
• W2742444091 hasAuthorship W2742444091A5079593433 @default.
• W2742444091 hasAuthorship W2742444091A5080500381 @default.
• W2742444091 hasConcept C104317684 @default.
• W2742444091 hasConcept C120405084 @default.
• W2742444091 hasConcept C121608353 @default.
• W2742444091 hasConcept C126322002 @default.
• W2742444091 hasConcept C149011108 @default.
• W2742444091 hasConcept C153911025 @default.
• W2742444091 hasConcept C185592680 @default.
• W2742444091 hasConcept C190283241 @default.
• W2742444091 hasConcept C2776912716 @default.
• W2742444091 hasConcept C2779761222 @default.
• W2742444091 hasConcept C2780256643 @default.
• W2742444091 hasConcept C2780616701 @default.
• W2742444091 hasConcept C28328180 @default.
• W2742444091 hasConcept C2993294228 @default.
• W2742444091 hasConcept C502942594 @default.
• W2742444091 hasConcept C526584372 @default.
• W2742444091 hasConcept C553184892 @default.
• W2742444091 hasConcept C55427017 @default.
• W2742444091 hasConcept C55493867 @default.
• W2742444091 hasConcept C71924100 @default.
• W2742444091 hasConcept C86554907 @default.
• W2742444091 hasConcept C86803240 @default.
• W2742444091 hasConcept C95444343 @default.
• W2742444091 hasConceptScore W2742444091C104317684 @default.
• W2742444091 hasConceptScore W2742444091C120405084 @default.
• W2742444091 hasConceptScore W2742444091C121608353 @default.
• W2742444091 hasConceptScore W2742444091C126322002 @default.
• W2742444091 hasConceptScore W2742444091C149011108 @default.
• W2742444091 hasConceptScore W2742444091C153911025 @default.
• W2742444091 hasConceptScore W2742444091C185592680 @default.
• W2742444091 hasConceptScore W2742444091C190283241 @default.
• W2742444091 hasConceptScore W2742444091C2776912716 @default.
• W2742444091 hasConceptScore W2742444091C2779761222 @default.
• W2742444091 hasConceptScore W2742444091C2780256643 @default.
• W2742444091 hasConceptScore W2742444091C2780616701 @default.
• W2742444091 hasConceptScore W2742444091C28328180 @default.
• W2742444091 hasConceptScore W2742444091C2993294228 @default.
• W2742444091 hasConceptScore W2742444091C502942594 @default.
• W2742444091 hasConceptScore W2742444091C526584372 @default.
• W2742444091 hasConceptScore W2742444091C553184892 @default.
• W2742444091 hasConceptScore W2742444091C55427017 @default.
• W2742444091 hasConceptScore W2742444091C55493867 @default.
• W2742444091 hasConceptScore W2742444091C71924100 @default.
• W2742444091 hasConceptScore W2742444091C86554907 @default.

• next