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• W2742445143 abstract "// Lavinia Raimondi 1, 2 , Angela De Luca 1, 2 , Viviana Costa 1, 2 , Nicola Amodio 3 , Valeria Carina 1, 2 , Daniele Bellavia 1, 2 , Pierfrancesco Tassone 3 , Stefania Pagani 5 , Milena Fini 5 , Riccardo Alessandro 4, 6 and Gianluca Giavaresi 2, 5 1 Rizzoli Orthopedic Institute, Bologna, Italy 2 Rizzoli Orthopedic Institute, Innovative Technology Platforms for Tissue Engineering, Theranostic and Oncology, Palermo, Italy 3 Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy 4 Biology and Genetics Unit, Department of Biopathology and Medical Biotechnology, University of Palermo, Palermo, Italy 5 Rizzoli Orthopedic Institute, Laboratory of Preclinical and Surgical Studies, Bologna, Italy 6 Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council, Palermo, Italy Correspondence to: Lavinia Raimondi, email: lavinia.raimondi@ior.it Keywords: biomarkers, osteosarcoma, personalized medicine, liquid biopsy, blood serum Received: May 10, 2017      Accepted: July 25, 2017      Published: August 03, 2017 ABSTRACT Osteosarcoma (OS) is a rare primary malignant bone tumour arising from primitive bone-forming mesenchymal cells, with high incidence in children and young adults, accounting for approximately 60% of all malignant bone tumours. Currently, long-term disease-free survival can be achieved by surgical treatment plus chemotherapy in approximately 60% of patients with localized extremity disease, and in 20–30% of patients with metastatic lung or bone disease. Diagnosis of primary lesions and recurrences is achieved by using radiological investigations and standard tissue biopsy, the latter being costly, painful and hardly repeatable for patients. Therefore, despite some recent advances, novel biomarkers for OS diagnosis, prediction of response to therapy, disease progression and chemoresistance, are urgently needed. Biological fluids such as blood represent a rich source of non-invasive cancer biomarkers, which allow to understand what is really happening inside the tumour, either at diagnosis or during disease progression. In this regard, liquid biopsy potentially represents an alternative and non-invasive method to detect tumour onset, progression and response to therapy. In this review, we will summarize the state of the art in this novel area, illustrating recent studies on OS. Although the data reported in literature seem preliminary, liquid biopsy represents a promising tool with the potential to be rapidly translated in the clinical practice." @default.
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• W2742445143 date "2017-08-03" @default.
• W2742445143 modified "2023-09-24" @default.
• W2742445143 title "Circulating biomarkers in osteosarcoma: new translational tools for diagnosis and treatment" @default.
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