Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742449822> ?p ?o ?g. }
- W2742449822 endingPage "1489" @default.
- W2742449822 startingPage "1476" @default.
- W2742449822 abstract "Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between samples. This should be considered when comparing expression profiles of normal and cancerous kidney tissues. We exploited these differences to define renal-cell-specific gene signatures and used these as a framework to analyze renal cell carcinoma (RCC) ontogeny. Chromophobe RCCs express FOXI1-driven genes that define collecting duct intercalated cells, whereas HNF-regulated genes, specific for proximal tubule cells, are an integral part of clear cell and papillary RCC transcriptomes. These networks may be used as a framework for understanding the interplay between genomic changes in RCC subtypes and the lineage-defining regulatory machinery of their non-neoplastic counterparts." @default.
- W2742449822 created "2017-08-17" @default.
- W2742449822 creator A5031028431 @default.
- W2742449822 creator A5033877696 @default.
- W2742449822 creator A5038564333 @default.
- W2742449822 creator A5039395168 @default.
- W2742449822 creator A5059516280 @default.
- W2742449822 creator A5065213537 @default.
- W2742449822 creator A5067215547 @default.
- W2742449822 creator A5077167332 @default.
- W2742449822 creator A5086987013 @default.
- W2742449822 creator A5090489810 @default.
- W2742449822 date "2017-08-01" @default.
- W2742449822 modified "2023-10-16" @default.
- W2742449822 title "Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes" @default.
- W2742449822 cites W1778095495 @default.
- W2742449822 cites W1801619426 @default.
- W2742449822 cites W1825602802 @default.
- W2742449822 cites W1979614927 @default.
- W2742449822 cites W1989755476 @default.
- W2742449822 cites W2007782538 @default.
- W2742449822 cites W2010991736 @default.
- W2742449822 cites W2012034410 @default.
- W2742449822 cites W2018838463 @default.
- W2742449822 cites W2021485215 @default.
- W2742449822 cites W2032528091 @default.
- W2742449822 cites W2042604174 @default.
- W2742449822 cites W2044737323 @default.
- W2742449822 cites W2062094438 @default.
- W2742449822 cites W2064862709 @default.
- W2742449822 cites W2068143018 @default.
- W2742449822 cites W2068202160 @default.
- W2742449822 cites W2071042193 @default.
- W2742449822 cites W2082331198 @default.
- W2742449822 cites W2085875626 @default.
- W2742449822 cites W2111410841 @default.
- W2742449822 cites W2111867681 @default.
- W2742449822 cites W2113466606 @default.
- W2742449822 cites W2115462905 @default.
- W2742449822 cites W2117897405 @default.
- W2742449822 cites W2124322010 @default.
- W2742449822 cites W2128942479 @default.
- W2742449822 cites W2138093501 @default.
- W2742449822 cites W2148615664 @default.
- W2742449822 cites W2152297969 @default.
- W2742449822 cites W2154694043 @default.
- W2742449822 cites W2159478099 @default.
- W2742449822 cites W2160042082 @default.
- W2742449822 cites W2170766140 @default.
- W2742449822 cites W2288944226 @default.
- W2742449822 cites W2335012284 @default.
- W2742449822 cites W2411664918 @default.
- W2742449822 doi "https://doi.org/10.1016/j.celrep.2017.07.043" @default.
- W2742449822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28793269" @default.
- W2742449822 hasPublicationYear "2017" @default.
- W2742449822 type Work @default.
- W2742449822 sameAs 2742449822 @default.
- W2742449822 citedByCount "67" @default.
- W2742449822 countsByYear W27424498222018 @default.
- W2742449822 countsByYear W27424498222019 @default.
- W2742449822 countsByYear W27424498222020 @default.
- W2742449822 countsByYear W27424498222021 @default.
- W2742449822 countsByYear W27424498222022 @default.
- W2742449822 countsByYear W27424498222023 @default.
- W2742449822 crossrefType "journal-article" @default.
- W2742449822 hasAuthorship W2742449822A5031028431 @default.
- W2742449822 hasAuthorship W2742449822A5033877696 @default.
- W2742449822 hasAuthorship W2742449822A5038564333 @default.
- W2742449822 hasAuthorship W2742449822A5039395168 @default.
- W2742449822 hasAuthorship W2742449822A5059516280 @default.
- W2742449822 hasAuthorship W2742449822A5065213537 @default.
- W2742449822 hasAuthorship W2742449822A5067215547 @default.
- W2742449822 hasAuthorship W2742449822A5077167332 @default.
- W2742449822 hasAuthorship W2742449822A5086987013 @default.
- W2742449822 hasAuthorship W2742449822A5090489810 @default.
- W2742449822 hasBestOaLocation W27424498221 @default.
- W2742449822 hasConcept C104317684 @default.
- W2742449822 hasConcept C121608353 @default.
- W2742449822 hasConcept C142724271 @default.
- W2742449822 hasConcept C1491633281 @default.
- W2742449822 hasConcept C150194340 @default.
- W2742449822 hasConcept C162317418 @default.
- W2742449822 hasConcept C189014844 @default.
- W2742449822 hasConcept C2777472916 @default.
- W2742449822 hasConcept C2777546739 @default.
- W2742449822 hasConcept C2778560582 @default.
- W2742449822 hasConcept C2780091579 @default.
- W2742449822 hasConcept C2781068499 @default.
- W2742449822 hasConcept C2781231759 @default.
- W2742449822 hasConcept C2781278892 @default.
- W2742449822 hasConcept C502942594 @default.
- W2742449822 hasConcept C54355233 @default.
- W2742449822 hasConcept C70721500 @default.
- W2742449822 hasConcept C71924100 @default.
- W2742449822 hasConcept C78795084 @default.
- W2742449822 hasConcept C86803240 @default.
- W2742449822 hasConcept C95444343 @default.
- W2742449822 hasConceptScore W2742449822C104317684 @default.