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- W2742472255 abstract "Introduction: Pentane is generated from the perioxidation reaction of free radicals with cellular membrane lipids, and may be a marker of inflammation. On the other hand, acetone is synthesized by liver cells by the decarboxylation of excess acetyl-CoA via fatty acid β-oxidation. Both pentane and acetone are readily detectable as volatile organic compounds in exhaled breath. Since prior studies have implicated that minute ventilation/carbon dioxide production (VE/VCO2) slope can be associated with elevated right ventricular oxidative metabolism (Ukkonen et al, Eur J Heart Fail 2008), we sought to investigate the relationships between exhaled pentane and acetone and dynamic nature ofmeasures of cardiopulmonary exercise testing (CPET). with sampling of VOCs. Traditional parameters of CPET such as minute ventilation/carbon dioxide production (Ve/VCO2) and peak oxygen consumption (peak VO2) are used as indicators of severity in heart failure. Methods: In a cohort of 50 patients undergoing CPET with a history of heart failure, exhaled levels of acetone and pentane were collected before and after exercise stress testing. SIFT-MS mass spectrometry was used to quantify twenty-two VOCs in the breath sample. Results: To determine if levels of exhaled VOCs correlated with traditional clinical indicators of heart failure severity, such asIn our study cohort (mean age 59 + /- 6 years, 70% male, mean LVEF 32%), we observed that compared to those with below median Ve/VCO2 (</=35.5), patients with above median Ve/VCO2 (>35.5) had significantly higher median initial resting exhaled acetone levels (211.95 ppb vs 118.19 ppb, P = .034), as well as significantly higher initial resting pentane levels (15.95ppb vs 11.68 ppn, P = .049). Post- exercise median level of acetone was also significantly higher in Group C compared to Group Dthose with above median Ve/VCO2. In contrast, baseline and post-exercise pentane and acetone were similar between those with higher vesus lower peak VO2. Summary: Baseline exhaled pentane and acetone levels were elevated in those with higher VE/VCO2 levels but not in those with lower peak VO2 levels. These findings corborrated with prior reports implicating elevated VE/VCO2 slope with elevated right ventricular oxidative metabolism." @default.
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- W2742472255 date "2017-08-01" @default.
- W2742472255 modified "2023-10-18" @default.
- W2742472255 title "Exhaled Acetone and Pentane in Patients Undergoing Cardiopulmonary Exercise Testing" @default.
- W2742472255 doi "https://doi.org/10.1016/j.cardfail.2017.07.080" @default.
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