FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742479560> ?p ?o ?g. }

• W2742479560 endingPage "1095" @default.
• W2742479560 startingPage "1088" @default.
• W2742479560 abstract "The redox coenzymes NADH and NADPH are broadly required for energy metabolism, biosynthesis and detoxification. Despite detailed knowledge of specific enzymes and pathways that utilize these coenzymes, a holistic understanding of the regulation and compartmentalization of NADH- and NADPH-dependent pathways is lacking, partly because of a lack of tools with which to investigate these processes in living cells. We have previously reported the use of the naturally occurring Lactobacillus brevis H2O-forming NADH oxidase (LbNOX) as a genetic tool for manipulation of the NAD+/NADH ratio in human cells. Here, we present triphosphopyridine nucleotide oxidase (TPNOX), a rationally designed and engineered mutant of LbNOX that is strictly specific to NADPH. We characterized the effects of TPNOX expression on cellular metabolism and used it in combination with LbNOX to show how the redox states of mitochondrial NADPH and NADH pools are connected." @default.
• W2742479560 created "2017-08-17" @default.
• W2742479560 creator A5005621524 @default.
• W2742479560 creator A5009756127 @default.
• W2742479560 creator A5013227164 @default.
• W2742479560 creator A5068971521 @default.
• W2742479560 creator A5089212972 @default.
• W2742479560 date "2017-08-07" @default.
• W2742479560 modified "2023-10-18" @default.
• W2742479560 title "A genetically encoded tool for manipulation of NADP+/NADPH in living cells" @default.
• W2742479560 cites W1525779234 @default.
• W2742479560 cites W1538529173 @default.
• W2742479560 cites W1542594322 @default.
• W2742479560 cites W1599096812 @default.
• W2742479560 cites W1702365358 @default.
• W2742479560 cites W1738677317 @default.
• W2742479560 cites W1748219386 @default.
• W2742479560 cites W1801184284 @default.
• W2742479560 cites W1894322524 @default.
• W2742479560 cites W1971413372 @default.
• W2742479560 cites W1977709336 @default.
• W2742479560 cites W1984770312 @default.
• W2742479560 cites W1985987885 @default.
• W2742479560 cites W2005954340 @default.
• W2742479560 cites W2014880757 @default.
• W2742479560 cites W2017035524 @default.
• W2742479560 cites W2017605218 @default.
• W2742479560 cites W2018257401 @default.
• W2742479560 cites W2031022790 @default.
• W2742479560 cites W2039197854 @default.
• W2742479560 cites W2043510269 @default.
• W2742479560 cites W2047898810 @default.
• W2742479560 cites W2055969761 @default.
• W2742479560 cites W2062840670 @default.
• W2742479560 cites W2070399999 @default.
• W2742479560 cites W2088242983 @default.
• W2742479560 cites W2094220946 @default.
• W2742479560 cites W2097487849 @default.
• W2742479560 cites W2100498403 @default.
• W2742479560 cites W2107554012 @default.
• W2742479560 cites W2108609254 @default.
• W2742479560 cites W2111066410 @default.
• W2742479560 cites W2121469024 @default.
• W2742479560 cites W2129536482 @default.
• W2742479560 cites W2138582650 @default.
• W2742479560 cites W2141004226 @default.
• W2742479560 cites W2155184340 @default.
• W2742479560 cites W2157205323 @default.
• W2742479560 cites W2166196545 @default.
• W2742479560 cites W2279449503 @default.
• W2742479560 cites W2284984697 @default.
• W2742479560 cites W2301341355 @default.
• W2742479560 cites W2302911970 @default.
• W2742479560 cites W2312291090 @default.
• W2742479560 cites W2314595191 @default.
• W2742479560 cites W2405069786 @default.
• W2742479560 cites W2417808664 @default.
• W2742479560 cites W2462743508 @default.
• W2742479560 cites W2523360402 @default.
• W2742479560 cites W4235520135 @default.
• W2742479560 cites W4254119740 @default.
• W2742479560 cites W4362172418 @default.
• W2742479560 doi "https://doi.org/10.1038/nchembio.2454" @default.
• W2742479560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605434" @default.
• W2742479560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28805804" @default.
• W2742479560 hasPublicationYear "2017" @default.
• W2742479560 type Work @default.
• W2742479560 sameAs 2742479560 @default.
• W2742479560 citedByCount "67" @default.
• W2742479560 countsByYear W27424795602018 @default.
• W2742479560 countsByYear W27424795602019 @default.
• W2742479560 countsByYear W27424795602020 @default.
• W2742479560 countsByYear W27424795602021 @default.
• W2742479560 countsByYear W27424795602022 @default.
• W2742479560 countsByYear W27424795602023 @default.
• W2742479560 crossrefType "journal-article" @default.
• W2742479560 hasAuthorship W2742479560A5005621524 @default.
• W2742479560 hasAuthorship W2742479560A5009756127 @default.
• W2742479560 hasAuthorship W2742479560A5013227164 @default.
• W2742479560 hasAuthorship W2742479560A5068971521 @default.
• W2742479560 hasAuthorship W2742479560A5089212972 @default.
• W2742479560 hasBestOaLocation W27424795602 @default.
• W2742479560 hasConcept C104317684 @default.
• W2742479560 hasConcept C110455231 @default.
• W2742479560 hasConcept C143065580 @default.
• W2742479560 hasConcept C181199279 @default.
• W2742479560 hasConcept C185592680 @default.
• W2742479560 hasConcept C197957613 @default.
• W2742479560 hasConcept C38485361 @default.
• W2742479560 hasConcept C512185932 @default.
• W2742479560 hasConcept C55493867 @default.
• W2742479560 hasConcept C57600042 @default.
• W2742479560 hasConcept C75520062 @default.
• W2742479560 hasConcept C86803240 @default.
• W2742479560 hasConcept C95444343 @default.
• W2742479560 hasConceptScore W2742479560C104317684 @default.
• W2742479560 hasConceptScore W2742479560C110455231 @default.
• W2742479560 hasConceptScore W2742479560C143065580 @default.

• next