Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742489071> ?p ?o ?g. }
- W2742489071 abstract "The limited effectiveness of conventional therapy for malignant pleural mesothelioma (MPM) demands innovative approaches to this difficult disease. Even with aggressive multimodality treatment of surgery, radiation, and/or chemotherapy, the median survival is only 1-2 years depending on stage and histology. Oncolytic viral therapy has emerged in the last several decades as a rapidly advancing field of immunotherapy studied in a wide spectrum of malignancies. Mesothelioma makes an ideal candidate for studying oncolysis given the frequently localized pattern of growth and pleural location providing access to direct intratumoral injection of virus. Therefore despite being a relatively uncommon disease, the multitude of viral studies for mesothelioma can provide insight for applying such therapy to other malignancies. This manuscript will begin with a review of the standard therapy for mesothelioma, followed by general principles of oncolytic therapy focusing on antitumor efficacy, tumor selectivity, and immune system activation. The second half of this review will detail results of preclinical models and human studies for oncolytic virotherapy in mesothelioma." @default.
- W2742489071 created "2017-08-17" @default.
- W2742489071 creator A5008573977 @default.
- W2742489071 creator A5014289302 @default.
- W2742489071 date "2017-08-24" @default.
- W2742489071 modified "2023-09-23" @default.
- W2742489071 title "Oncolytic Viral Therapy for Mesothelioma" @default.
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