Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742491034> ?p ?o ?g. }
- W2742491034 endingPage "272" @default.
- W2742491034 startingPage "263" @default.
- W2742491034 abstract "Background/Objective:The aim of the present study was to investigate predictors of atypical antipsychotic (AAP) treatment continuation and response by week 8 in patients with Alzheimer’s disease (AD) who have psychotic/aggressive symptoms using the Clinical Antipsychotic Trials of Intervention Effe ctiveness–Alzheimer’s Disease (CATIE-AD) dataset. Methods:Clinical data was utilized from 421 AD outpatients with psychotic/aggressive symptoms who needed interventional treatment. Logistic regression analyses were performed to examine which baseline sociodemographic and clinical characteristics contributed to treatment ‘continuation’ and ‘response’, the latter of which was evaluated by the Clinical Global Impression of Change (CGI-C), Neuropsychiatric Inventory (NPI), and Brief Psychiatric Scale (BPRS). Results:The treatment continuation rate was 48.7%, and CGI-C, NPI, and BPRS response rate by the last observation carried forward method were 42.7%, 48.6%, and 37.5%, respectively. No significant predictor was identified for treatment continuation in the Caucasian patients (n = 331), while better treatment response was predicted by a lower Mini-Mental State Examination score, treatment with risperidone (versus olanzapine and quetiapine), history of diabetes mellitus, healthier physical status, and more severe initial psychotic symptoms. Conclusions:Comparatively high intolerability from AAPs in the short term was confirmed. We found that baseline clinical predictors to treatment response in Caucasian AD patients with psychotic/aggressive symptoms include treatment with risperidone (versus quetiapine and olanzapine), diabetes mellitus, global physical status, cognitive impairment, and psychotic symptoms. Going forward, these findings may help to determine treatment strategies or care plans." @default.
- W2742491034 created "2017-08-17" @default.
- W2742491034 creator A5031423812 @default.
- W2742491034 creator A5033519257 @default.
- W2742491034 creator A5044700950 @default.
- W2742491034 creator A5044840695 @default.
- W2742491034 creator A5055174569 @default.
- W2742491034 creator A5057023665 @default.
- W2742491034 creator A5064812413 @default.
- W2742491034 date "2017-08-29" @default.
- W2742491034 modified "2023-10-18" @default.
- W2742491034 title "Baseline Predictors of Antipsychotic Treatment Continuation and Response at Week 8 in Patients with Alzheimer’s Disease with Psychosis or Aggressive Symptoms: An Analysis of the CATIE-AD Study" @default.
- W2742491034 cites W1164896577 @default.
- W2742491034 cites W1496470611 @default.
- W2742491034 cites W1522622114 @default.
- W2742491034 cites W1565231669 @default.
- W2742491034 cites W1647486168 @default.
- W2742491034 cites W1847168837 @default.
- W2742491034 cites W1983850663 @default.
- W2742491034 cites W1992109356 @default.
- W2742491034 cites W1992139786 @default.
- W2742491034 cites W1996567609 @default.
- W2742491034 cites W1996776294 @default.
- W2742491034 cites W1997209784 @default.
- W2742491034 cites W1999066172 @default.
- W2742491034 cites W2011666842 @default.
- W2742491034 cites W2016239314 @default.
- W2742491034 cites W2023764011 @default.
- W2742491034 cites W2028471410 @default.
- W2742491034 cites W2031924880 @default.
- W2742491034 cites W2058762304 @default.
- W2742491034 cites W2060552050 @default.
- W2742491034 cites W2060664873 @default.
- W2742491034 cites W2068185188 @default.
- W2742491034 cites W2073188741 @default.
- W2742491034 cites W2074349167 @default.
- W2742491034 cites W2078394222 @default.
- W2742491034 cites W2105915837 @default.
- W2742491034 cites W2115235249 @default.
- W2742491034 cites W2124214624 @default.
- W2742491034 cites W2125346945 @default.
- W2742491034 cites W2130900065 @default.
- W2742491034 cites W2130913536 @default.
- W2742491034 cites W2132592055 @default.
- W2742491034 cites W2132871355 @default.
- W2742491034 cites W2138883123 @default.
- W2742491034 cites W2139614216 @default.
- W2742491034 cites W2143987649 @default.
- W2742491034 cites W2151391567 @default.
- W2742491034 cites W2151585937 @default.
- W2742491034 cites W2165939637 @default.
- W2742491034 cites W2166800323 @default.
- W2742491034 cites W2167862712 @default.
- W2742491034 cites W2169849640 @default.
- W2742491034 cites W2170049745 @default.
- W2742491034 cites W2228034364 @default.
- W2742491034 cites W2236030964 @default.
- W2742491034 cites W2329441002 @default.
- W2742491034 cites W2528048032 @default.
- W2742491034 doi "https://doi.org/10.3233/jad-170412" @default.
- W2742491034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28800334" @default.
- W2742491034 hasPublicationYear "2017" @default.
- W2742491034 type Work @default.
- W2742491034 sameAs 2742491034 @default.
- W2742491034 citedByCount "7" @default.
- W2742491034 countsByYear W27424910342018 @default.
- W2742491034 countsByYear W27424910342019 @default.
- W2742491034 countsByYear W27424910342020 @default.
- W2742491034 countsByYear W27424910342022 @default.
- W2742491034 crossrefType "journal-article" @default.
- W2742491034 hasAuthorship W2742491034A5031423812 @default.
- W2742491034 hasAuthorship W2742491034A5033519257 @default.
- W2742491034 hasAuthorship W2742491034A5044700950 @default.
- W2742491034 hasAuthorship W2742491034A5044840695 @default.
- W2742491034 hasAuthorship W2742491034A5055174569 @default.
- W2742491034 hasAuthorship W2742491034A5057023665 @default.
- W2742491034 hasAuthorship W2742491034A5064812413 @default.
- W2742491034 hasConcept C118552586 @default.
- W2742491034 hasConcept C126322002 @default.
- W2742491034 hasConcept C142724271 @default.
- W2742491034 hasConcept C15744967 @default.
- W2742491034 hasConcept C204787440 @default.
- W2742491034 hasConcept C27081682 @default.
- W2742491034 hasConcept C2776000289 @default.
- W2742491034 hasConcept C2776412080 @default.
- W2742491034 hasConcept C2776619155 @default.
- W2742491034 hasConcept C2778528637 @default.
- W2742491034 hasConcept C2779727114 @default.
- W2742491034 hasConcept C2780057945 @default.
- W2742491034 hasConcept C2780494398 @default.
- W2742491034 hasConcept C2780634440 @default.
- W2742491034 hasConcept C71924100 @default.
- W2742491034 hasConceptScore W2742491034C118552586 @default.
- W2742491034 hasConceptScore W2742491034C126322002 @default.
- W2742491034 hasConceptScore W2742491034C142724271 @default.
- W2742491034 hasConceptScore W2742491034C15744967 @default.
- W2742491034 hasConceptScore W2742491034C204787440 @default.
- W2742491034 hasConceptScore W2742491034C27081682 @default.