FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W27425794> ?p ?o ?g. }

• W27425794 abstract "Reducing body temperature to 33 °C in patients who have been resuscitated from cardiac arrest but who remain comatose can ameliorate anoxic encephalopathy and improve recovery. Experimental animal studies have suggested that cooling to 33 °C also aids the resuscitative process itself, facilitating the resumption of spontaneous circulation (ROSC). The mechanism of cooling benefit is probably the reduction of metabolic demand of most organs, and reduced production of toxic metabolites and reactive oxygen species. External cooling by application of ice or pads through which cold water circulates is effective but requires up to 8 hours to achieve the target temperature of 33 °C. Our goal was to develop a faster method of cooling that could be initiated during cardiopulmonary resuscitation. In anesthetized swine, we induced ventricular fibrillation by passing alternating current down an electrode catheter in the right ventricle. We then ventilated the animals' lungs with liquid perfluorocarbons (PFCs), a technique known as total liquid ventilation (TLV). Perfluorocarbons are oxygen-carrying modules; we pre-oxygenated the PFCs by bubbling 100% O(2) through the solution for 2 minutes before use, and pre-cooled the PFCs to -15 °C. The cold oxygenated PFCs reduced pulmonary artery temperature (a surrogate for myocardial temperature) to 33 °C in about 6 minutes. Using this technique we achieved ROSC in 8 of 11 (82%) animals given TLV versus 3 of 11 (27%) control animals receiving conventional CPR without PFCs (P<0.05). We also compared the cold TLV technique with the administration of intravenous iced saline to achieve hypothermia. Both the cold TLV and cold saline techniques produced rapid hypothermia, but we could achieve ROSC in only 2 of 8 (25%) animals given cold saline versus 7 of 8 (88%) given cold TLV. This result is likely due to the rise in right atrial pressure and corresponding reduction in coronary perfusion pressure caused by volume loading with IV saline, in addition to the higher pO(2) associated with pre-oxygenated PFCs. Cold TLV is a promising technique for achieving rapid intra-arrest and post-resuscitation hypothermia in patients experiencing cardiac arrest." @default.
• W27425794 created "2016-06-24" @default.
• W27425794 creator A5048232778 @default.
• W27425794 date "2011-01-01" @default.
• W27425794 modified "2023-09-23" @default.
• W27425794 title "Therapeutic Hypothermia: What's Hot about Cold." @default.
• W27425794 cites W1503600085 @default.
• W27425794 cites W1989842027 @default.
• W27425794 cites W1996178602 @default.
• W27425794 cites W2004917927 @default.
• W27425794 cites W2013284267 @default.
• W27425794 cites W2019232036 @default.
• W27425794 cites W2028072481 @default.
• W27425794 cites W2062642814 @default.
• W27425794 cites W2104869294 @default.
• W27425794 cites W2112164385 @default.
• W27425794 cites W2142364136 @default.
• W27425794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3116358" @default.
• W27425794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21686209" @default.
• W27425794 hasPublicationYear "2011" @default.
• W27425794 type Work @default.
• W27425794 sameAs 27425794 @default.
• W27425794 citedByCount "0" @default.
• W27425794 crossrefType "journal-article" @default.
• W27425794 hasAuthorship W27425794A5048232778 @default.
• W27425794 hasConcept C127413603 @default.
• W27425794 hasConcept C164705383 @default.
• W27425794 hasConcept C200457457 @default.
• W27425794 hasConcept C2777055891 @default.
• W27425794 hasConcept C2777390192 @default.
• W27425794 hasConcept C2778165595 @default.
• W27425794 hasConcept C2778921608 @default.
• W27425794 hasConcept C2781005686 @default.
• W27425794 hasConcept C42219234 @default.
• W27425794 hasConcept C71924100 @default.
• W27425794 hasConcept C78519656 @default.
• W27425794 hasConceptScore W27425794C127413603 @default.
• W27425794 hasConceptScore W27425794C164705383 @default.
• W27425794 hasConceptScore W27425794C200457457 @default.
• W27425794 hasConceptScore W27425794C2777055891 @default.
• W27425794 hasConceptScore W27425794C2777390192 @default.
• W27425794 hasConceptScore W27425794C2778165595 @default.
• W27425794 hasConceptScore W27425794C2778921608 @default.
• W27425794 hasConceptScore W27425794C2781005686 @default.
• W27425794 hasConceptScore W27425794C42219234 @default.
• W27425794 hasConceptScore W27425794C71924100 @default.
• W27425794 hasConceptScore W27425794C78519656 @default.
• W27425794 hasLocation W274257941 @default.
• W27425794 hasOpenAccess W27425794 @default.
• W27425794 hasPrimaryLocation W274257941 @default.
• W27425794 hasRelatedWork W153251688 @default.
• W27425794 hasRelatedWork W155327448 @default.
• W27425794 hasRelatedWork W1964910516 @default.
• W27425794 hasRelatedWork W2001384789 @default.
• W27425794 hasRelatedWork W2069809494 @default.
• W27425794 hasRelatedWork W2097373104 @default.
• W27425794 hasRelatedWork W2121714044 @default.
• W27425794 hasRelatedWork W2139579856 @default.
• W27425794 hasRelatedWork W2143943928 @default.
• W27425794 hasRelatedWork W2170012487 @default.
• W27425794 hasRelatedWork W2185559017 @default.
• W27425794 hasRelatedWork W2329635397 @default.
• W27425794 hasRelatedWork W2565136568 @default.
• W27425794 hasRelatedWork W2591536581 @default.
• W27425794 hasRelatedWork W2787524054 @default.
• W27425794 hasRelatedWork W2968216482 @default.
• W27425794 hasRelatedWork W3132191792 @default.
• W27425794 hasRelatedWork W58796315 @default.
• W27425794 hasRelatedWork W83911997 @default.
• W27425794 hasRelatedWork W2977680942 @default.
• W27425794 isParatext "false" @default.
• W27425794 isRetracted "false" @default.
• W27425794 magId "27425794" @default.
• W27425794 workType "article" @default.