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• W2742584148 abstract "An R-loop is a DNA:RNA hybrid formed during transcription when a DNA duplex is invaded by a nascent RNA transcript. R-loops accumulate in nucleoli during RNA polymerase I (RNAP I) transcription. Here, we report that mammalian RNase H1 enriches in nucleoli and co-localizes with R-loops in cultured human cells. Co-migration of RNase H1 and R-loops from nucleoli to perinucleolar ring structures was observed upon inhibition of RNAP I transcription. Treatment with camptothecin which transiently stabilized nucleolar R-loops recruited RNase H1 to the nucleoli. It has been reported that the absence of Topoisomerase and RNase H activity in Escherichia coli or Saccharomyces cerevisiae caused R-loop accumulation along rDNA. We found that the distribution of RNase H1 and Top1 along rDNA coincided at sites where R-loops accumulated in mammalian cells. Loss of either RNase H1 or Top1 caused R-loop accumulation, and the accumulation of R-loops was exacerbated when both proteins were depleted. Importantly, we observed that protein levels of Top1 were negatively correlated with the abundance of RNase H1. We conclude that Top1 and RNase H1 are partially functionally redundant in mammalian cells to suppress RNAP I transcription-associate R-loops." @default.
• W2742584148 created "2017-08-17" @default.
• W2742584148 creator A5014168187 @default.
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• W2742584148 date "2017-08-09" @default.
• W2742584148 modified "2023-10-01" @default.
• W2742584148 title "Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops" @default.
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• W2742584148 doi "https://doi.org/10.1093/nar/gkx710" @default.
• W2742584148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5737507" @default.
• W2742584148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28977560" @default.
• W2742584148 hasPublicationYear "2017" @default.
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