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• W2742624084 abstract "Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of β -amyloid (A β ) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented A β oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells. A β oligomers inhibited the prosurvival phosphoinositide 3-kinase (PI3K)/Akt cascade and activated the proapoptotic extracellular signal-regulated kinase (ERK) pathway. Moreover, inhibitors of glycogen synthase kinase 3 β (GSK3 β ) and mitogen-activated protein kinase (MEK) synergistically prevented A β oligomer-induced neuronal death, suggesting that the PI3K/Akt and ERK pathways might be involved in A β oligomer-induced neurotoxicity. Pretreatment with fucoxanthin significantly prevented A β oligomer-induced alteration of the PI3K/Akt and ERK pathways. Furthermore, LY294002 and wortmannin, two PI3K inhibitors, abolished the neuroprotective effects of fucoxanthin against A β oligomer-induced neurotoxicity. These results suggested that fucoxanthin might prevent A β oligomer-induced neuronal loss and oxidative stress via the activation of the PI3K/Akt cascade as well as inhibition of the ERK pathway, indicating that further studies of fucoxanthin and related compounds might lead to a useful treatment of AD." @default.
• W2742624084 created "2017-08-17" @default.
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• W2742624084 date "2017-01-01" @default.
• W2742624084 modified "2023-10-18" @default.
• W2742624084 title "Fucoxanthin, a Marine Carotenoid, Attenuates <i>β</i>-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells" @default.
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• W2742624084 doi "https://doi.org/10.1155/2017/6792543" @default.
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