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- W2742649208 abstract "Background: Ventricular volume overload causing mechanical wall stress has been suspected of causing exaggeration of transmural dispersion of repolarization. We hypothesized that the T peak to T end interval (Tpe) as measured on the surface electrocardiogram (EKG) and presumed to be the surrogate of transmural dispersion of repolarization is related to measurements by the Swan Ganz (SG) pulmonary artery (PA) catheter indicating the volume status in patients admitted to hospital for presumed acute decompensated heart failure. Methods: Retrospective review of patient records admitted to the heart failure unit at our institution in 2015 for goal directed therapy using Swan Ganz monitoring as well as having a documented EKG at admission and discharge or follow up when they were deemed euvolemic. After de identification and blinding, the Tpe interval as defined by the standard tangent method was measured using electronic calipers. Admission Tpe measurements were then compared to those at discharge or follow up. All clinical characteristics including SG measurements during their treatment are documented for comparison. Results: In a total of 100 subjects, the mean Tpe (milliseconds) during volume overloaded state was 2.43 compared to 2.01 post diuresis or at follow up (P < .001). The mean pulmonary capillary wedge pressure (PCWP) during volume overloaded state was 29.84 mmHg compared to 16.75 mmHg post diuresis (P < .001). There seemed to be a positive trend between the change in Tpe and simultaneous reduction in PCWP (r = 0.16), however the correlation seemed stronger in those patients whose Tpe improved better than the median (r = 0.25) than those who did not improve at all or improved less than the median (r = 0.13). Patients who were paced seemed to have a weaker correlation (r = 0.02) than non-paced subjects (r = 0.21). Patients without a pacer and whose Tpe improved more than the median had the best correlation (r = 0.40) Conclusions: Subjects whose Tpe improved better than median seem to have better correlation between Tpe and PA pressures than those whose Tpe improved marginally or not at all. Non Paced subjects correlated better that paced subjects. Tpe may have a potential in the prediction of volume overloaded state in heart failure patients." @default.
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- W2742649208 date "2017-08-01" @default.
- W2742649208 modified "2023-09-26" @default.
- W2742649208 title "Relationship between the Transmural Dispersion of Repolarization and Left Atrial Pressure during Diuresis in a Volume Overloaded State" @default.
- W2742649208 doi "https://doi.org/10.1016/j.cardfail.2017.07.198" @default.
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