Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742704755> ?p ?o ?g. }
- W2742704755 endingPage "93" @default.
- W2742704755 startingPage "85" @default.
- W2742704755 abstract "Although the central nervous system does not regenerate, injury induces repair and regenerative responses in glial cells. In mammals, activated microglia clear up apoptotic cells and debris resulting from the injury, astrocytes form a scar that contains the lesion, and NG2-glia elicit a prominent regenerative response. NG2-glia regenerate themselves and differentiate into oligodendrocytes, which remyelinate axons leading to some recovery of locomotion. The regenerative response of glial cells is evolutionarily conserved across the animals and Drosophila genetics revealed an underlying gene network. This involves the genes Notch, kon-tiki, eiger, dorsal, and prospero, homologues of mammalian Notch1, ng2, TNF, NFκB, and prox1, respectively. Feedback loops between these genes enable a surge in proliferation in response to injury and ensuing differentiation. Negative feedback sets a timer for proliferation, and prevents uncontrolled growth that could lead to glioma. Remarkable parallels are found in these genetic relationships between fruit flies and mammals. Drosophila findings provide insights into gene functions that could be manipulated in stem cells and progenitors for therapeutic repair. Developmental Dynamics 247:85–93, 2018. © 2017 Wiley Periodicals, Inc." @default.
- W2742704755 created "2017-08-17" @default.
- W2742704755 creator A5029160758 @default.
- W2742704755 creator A5038667422 @default.
- W2742704755 creator A5089293101 @default.
- W2742704755 date "2017-09-25" @default.
- W2742704755 modified "2023-10-17" @default.
- W2742704755 title "Gene network underlying the glial regenerative response to central nervous system injury" @default.
- W2742704755 cites W1491124395 @default.
- W2742704755 cites W1509596990 @default.
- W2742704755 cites W1575907081 @default.
- W2742704755 cites W1606121723 @default.
- W2742704755 cites W1625025208 @default.
- W2742704755 cites W1822318929 @default.
- W2742704755 cites W1859477582 @default.
- W2742704755 cites W1865973687 @default.
- W2742704755 cites W1894035827 @default.
- W2742704755 cites W1968195620 @default.
- W2742704755 cites W1969619562 @default.
- W2742704755 cites W1970901436 @default.
- W2742704755 cites W1972945472 @default.
- W2742704755 cites W1976292214 @default.
- W2742704755 cites W1977630786 @default.
- W2742704755 cites W1985084268 @default.
- W2742704755 cites W1985286185 @default.
- W2742704755 cites W1986918091 @default.
- W2742704755 cites W1987798862 @default.
- W2742704755 cites W1987885030 @default.
- W2742704755 cites W1991279445 @default.
- W2742704755 cites W1993076702 @default.
- W2742704755 cites W1994825168 @default.
- W2742704755 cites W1995860861 @default.
- W2742704755 cites W1997576057 @default.
- W2742704755 cites W2000630772 @default.
- W2742704755 cites W2002425839 @default.
- W2742704755 cites W2002943068 @default.
- W2742704755 cites W2003485988 @default.
- W2742704755 cites W2003769148 @default.
- W2742704755 cites W2006312185 @default.
- W2742704755 cites W2007924879 @default.
- W2742704755 cites W2009156079 @default.
- W2742704755 cites W2010050268 @default.
- W2742704755 cites W2013479098 @default.
- W2742704755 cites W2021772999 @default.
- W2742704755 cites W2022001110 @default.
- W2742704755 cites W2025392916 @default.
- W2742704755 cites W2025477103 @default.
- W2742704755 cites W2027215260 @default.
- W2742704755 cites W2028104467 @default.
- W2742704755 cites W2033322963 @default.
- W2742704755 cites W2035098555 @default.
- W2742704755 cites W2035389484 @default.
- W2742704755 cites W2036197904 @default.
- W2742704755 cites W2045013955 @default.
- W2742704755 cites W2046542852 @default.
- W2742704755 cites W2047998784 @default.
- W2742704755 cites W2048082433 @default.
- W2742704755 cites W2049485433 @default.
- W2742704755 cites W2050596253 @default.
- W2742704755 cites W2053363717 @default.
- W2742704755 cites W2059574895 @default.
- W2742704755 cites W2063639010 @default.
- W2742704755 cites W2066256704 @default.
- W2742704755 cites W2070352232 @default.
- W2742704755 cites W2072516242 @default.
- W2742704755 cites W2073133778 @default.
- W2742704755 cites W2073343110 @default.
- W2742704755 cites W2074132398 @default.
- W2742704755 cites W2075008638 @default.
- W2742704755 cites W2077714658 @default.
- W2742704755 cites W2082178383 @default.
- W2742704755 cites W2082585155 @default.
- W2742704755 cites W2083076780 @default.
- W2742704755 cites W2083102961 @default.
- W2742704755 cites W2087851322 @default.
- W2742704755 cites W2089973529 @default.
- W2742704755 cites W2090177945 @default.
- W2742704755 cites W2094416985 @default.
- W2742704755 cites W2098814204 @default.
- W2742704755 cites W2099102304 @default.
- W2742704755 cites W2104706868 @default.
- W2742704755 cites W2104968232 @default.
- W2742704755 cites W2110309782 @default.
- W2742704755 cites W2115967857 @default.
- W2742704755 cites W2117577687 @default.
- W2742704755 cites W2119466467 @default.
- W2742704755 cites W2121860798 @default.
- W2742704755 cites W2124940469 @default.
- W2742704755 cites W2125236750 @default.
- W2742704755 cites W2125573110 @default.
- W2742704755 cites W2126464408 @default.
- W2742704755 cites W2130848106 @default.
- W2742704755 cites W2138635257 @default.
- W2742704755 cites W2143311793 @default.
- W2742704755 cites W2144593635 @default.
- W2742704755 cites W2145404211 @default.
- W2742704755 cites W2145430495 @default.
- W2742704755 cites W2148353419 @default.