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- W2742723985 abstract "Ciprofloxacin (CIP) has been widely used to treat many types of bacterial infections. Herein, we reported a green approach for preparation of CIP nanoparticles via solvent anti-solvent precipitation by using subcritical water-ethanol mixture as the solvent. The solubility of CIP in subcritical water-ethanol mixture (with various ethanol ratio of 0, 5, and 20 wt%) at the temperature range from 100 °C to 170 °C and constant pressure of 4 MPa were measured. The chemical structure of CIP was stable after processed in subcritical water-ethanol mixture at up to 170 °C, confirmed by Fourier transformed infrared analysis. The obtained solubility data of CIP were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. The nanonization of CIP via solvent anti-solvent precipitation process that used the tunable solvent power of subcritical water-ethanol mixture was conducted. Two kinds of no-ionic, hydrophilic polymer, including polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG), were introduced as stabilizers in the precipitation process to obtain CIP nanoparticle with improved dissolution rate. These results show that as-synthesized CIP nanoparticles are promising for oral administration of CIP drugs." @default.
- W2742723985 created "2017-08-17" @default.
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- W2742723985 date "2017-11-01" @default.
- W2742723985 modified "2023-10-14" @default.
- W2742723985 title "Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters" @default.
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- W2742723985 doi "https://doi.org/10.1016/j.powtec.2017.08.038" @default.
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