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- W2742755194 abstract "Significance Emotional arousal creates lasting and vivid memories. According to the systems consolidation theory, the hippocampus has a time-limited role in memory, and retrieval of remote memories mainly relies on neocortical networks. Here we show that this systems consolidation and associated change in memory specificity constitute a dynamically regulated process that can be modified by emotional arousal status. Norepinephrine administration into the basolateral amygdala after an episodic-like training experience maintained accuracy and hippocampus dependency of remote memory. This altered systems consolidation was paralleled by time-regulated epigenetically driven transcriptional changes of memory-related genes in the hippocampus and neocortex." @default.
- W2742755194 created "2017-08-17" @default.
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- W2742755194 date "2017-08-08" @default.
- W2742755194 modified "2023-10-15" @default.
- W2742755194 title "Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory" @default.
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- W2742755194 doi "https://doi.org/10.1073/pnas.1710819114" @default.
- W2742755194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5576838" @default.
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