FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742760241> ?p ?o ?g. }

• W2742760241 endingPage "2717" @default.
• W2742760241 startingPage "2706" @default.
• W2742760241 abstract "DNA repair protects genomic integrity and may modulate chemotherapy efficacy. Few large-scale studies have evaluated predictive roles of genetic variants of DNA repair genes in survival of Chinese gastric cancer (GCa) patients treated with chemotherapy. Here, we assessed the roles of 35 single nucleotide polymorphisms (SNPs) in DNA repair genes in survival of 1002 GCa patients, of whom 694 received chemotherapy and 308 did not. Among patients receiving chemotherapy, the ERCC1 rs2298881A allele was associated with a better survival [hazards ratio (HR) = 0.82, 95% confidence interval (CI) = 0.69-0.98; P = 0.03], whereas two XRCC4 SNPs were associated with a worse survival (HR = 1.26, 95% CI = 1.03-1.54 for the rs10040363G allele, P = 0.02; and HR = 1.30, 95% CI = 1.06-1.59 for the rs2075685T allele, P = 0.01). These three SNPs were unique survival predictors for patients treated with chemotherapy (P < 0.05 for all) but not for patients without chemotherapy (P > 0.05 for all), suggesting that they modulated chemotherapy efficacy. Patients who received chemotherapy and had haplotypes with at least one death-risk allele in XRCC4 had a poor survival, and the trend for an increase in the number of death-risk alleles adversely affecting the survival was also observed in an allelic dose-dependent manner (Ptrend = 0.001). Further functional analysis revealed that the death-risk alleles up-regulated the gene expression, leading to a worse survival as suggested by our meta-analysis pooling both mRNA microarray data from the GEO database and published data (ERCC1: HR = 1.31 [1.08-1.58]; P = 0.006). These functional genetic variants may independently or jointly affect survival in chemotherapy-treated GCa patients by modulating the gene expression in the tumors." @default.
• W2742760241 created "2017-08-17" @default.
• W2742760241 creator A5009692975 @default.
• W2742760241 creator A5033941158 @default.
• W2742760241 creator A5056062916 @default.
• W2742760241 creator A5058433699 @default.
• W2742760241 creator A5081855304 @default.
• W2742760241 creator A5082250226 @default.
• W2742760241 creator A5084985894 @default.
• W2742760241 creator A5086903174 @default.
• W2742760241 date "2017-09-11" @default.
• W2742760241 modified "2023-09-27" @default.
• W2742760241 title "Functional genetic variants of <i>XRCC4</i> and <i>ERCC1</i> predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression" @default.
• W2742760241 cites W12636511 @default.
• W2742760241 cites W1534578968 @default.
• W2742760241 cites W1549355129 @default.
• W2742760241 cites W1592416724 @default.
• W2742760241 cites W1975030858 @default.
• W2742760241 cites W1979317251 @default.
• W2742760241 cites W1980438635 @default.
• W2742760241 cites W1984720118 @default.
• W2742760241 cites W2000478520 @default.
• W2742760241 cites W2002753352 @default.
• W2742760241 cites W2009326542 @default.
• W2742760241 cites W2012071848 @default.
• W2742760241 cites W2014260980 @default.
• W2742760241 cites W2036223578 @default.
• W2742760241 cites W2040413443 @default.
• W2742760241 cites W2049397238 @default.
• W2742760241 cites W2053132317 @default.
• W2742760241 cites W2054700834 @default.
• W2742760241 cites W2083202264 @default.
• W2742760241 cites W2098719201 @default.
• W2742760241 cites W2101831300 @default.
• W2742760241 cites W2102945991 @default.
• W2742760241 cites W2104298639 @default.
• W2742760241 cites W2105067796 @default.
• W2742760241 cites W2109468970 @default.
• W2742760241 cites W2140079981 @default.
• W2742760241 cites W2141037581 @default.
• W2742760241 cites W2145135839 @default.
• W2742760241 cites W2149895338 @default.
• W2742760241 cites W2153105150 @default.
• W2742760241 cites W2161308107 @default.
• W2742760241 cites W2163731055 @default.
• W2742760241 cites W2164411042 @default.
• W2742760241 cites W2170454539 @default.
• W2742760241 cites W2272984102 @default.
• W2742760241 cites W2461061115 @default.
• W2742760241 cites W2463540776 @default.
• W2742760241 cites W2472165391 @default.
• W2742760241 cites W2498161851 @default.
• W2742760241 cites W2528741765 @default.
• W2742760241 cites W2616126806 @default.
• W2742760241 doi "https://doi.org/10.1002/mc.22713" @default.
• W2742760241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28796378" @default.
• W2742760241 hasPublicationYear "2017" @default.
• W2742760241 type Work @default.
• W2742760241 sameAs 2742760241 @default.
• W2742760241 citedByCount "4" @default.
• W2742760241 countsByYear W27427602412018 @default.
• W2742760241 countsByYear W27427602412019 @default.
• W2742760241 countsByYear W27427602412021 @default.
• W2742760241 countsByYear W27427602412023 @default.
• W2742760241 crossrefType "journal-article" @default.
• W2742760241 hasAuthorship W2742760241A5009692975 @default.
• W2742760241 hasAuthorship W2742760241A5033941158 @default.
• W2742760241 hasAuthorship W2742760241A5056062916 @default.
• W2742760241 hasAuthorship W2742760241A5058433699 @default.
• W2742760241 hasAuthorship W2742760241A5081855304 @default.
• W2742760241 hasAuthorship W2742760241A5082250226 @default.
• W2742760241 hasAuthorship W2742760241A5084985894 @default.
• W2742760241 hasAuthorship W2742760241A5086903174 @default.
• W2742760241 hasConcept C104317684 @default.
• W2742760241 hasConcept C104451858 @default.
• W2742760241 hasConcept C10515644 @default.
• W2742760241 hasConcept C121608353 @default.
• W2742760241 hasConcept C126322002 @default.
• W2742760241 hasConcept C134935766 @default.
• W2742760241 hasConcept C135763542 @default.
• W2742760241 hasConcept C143998085 @default.
• W2742760241 hasConcept C153209595 @default.
• W2742760241 hasConcept C180754005 @default.
• W2742760241 hasConcept C197754878 @default.
• W2742760241 hasConcept C207103383 @default.
• W2742760241 hasConcept C2776694085 @default.
• W2742760241 hasConcept C2779309665 @default.
• W2742760241 hasConcept C44249647 @default.
• W2742760241 hasConcept C54355233 @default.
• W2742760241 hasConcept C71924100 @default.
• W2742760241 hasConcept C86803240 @default.
• W2742760241 hasConceptScore W2742760241C104317684 @default.
• W2742760241 hasConceptScore W2742760241C104451858 @default.
• W2742760241 hasConceptScore W2742760241C10515644 @default.
• W2742760241 hasConceptScore W2742760241C121608353 @default.
• W2742760241 hasConceptScore W2742760241C126322002 @default.
• W2742760241 hasConceptScore W2742760241C134935766 @default.
• W2742760241 hasConceptScore W2742760241C135763542 @default.

• next