FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742767384> ?p ?o ?g. }

• W2742767384 endingPage "128" @default.
• W2742767384 startingPage "119" @default.
• W2742767384 abstract "Hyperthyroidism (HT) is characterized by an intense metabolic impact which affects the lipid, carbohydrate and amino acids metabolism, with increased resting energy expenditure and thermogenesis. Metabolomics is a new comprehensive technique that allows to capture an instant metabolic picture of an organism, reflecting peculiar molecular and pathophysiological states. The aim of the present prospective study was to identify a distinct metabolomic profile in HT patients using 1H NMR spectroscopy before and after antithyroid drug treatment. This prospective study included 15 patients (10 female, 5 male) who were newly diagnosed hyperthyroidism. A nuclear magnetic resonance (1H NMR) based analysis was performed on plasma samples from the same patients at diagnosis (HypT0) and when they achieved euthyroidism (HypT1). The case groups were compared with a control group of 26 healthy volunteers (C). Multivariate statistical analysis was performed with Partial Least Squares-Discriminant Analysis (PLS-DA). PLS-DA identified a distinct metabolic profile between C and untreated hyperthyroid patients (R2X 0.638, R2Y 0.932, Q2 0.783). Interestingly, a significant difference was also found between C and euthyroid patients after treatment (R2X 0.510, R2Y 0.838, Q2 0.607), while similar cluster emerged comparing HypT0 vs HypT1 patients. This study shows that metabolomic profile is deeply influenced by hyperthyroidism and this alteration persists after normalization of thyrotropin (TSH) and free thyroid hormone (FT3, FT4) concentration. This suggests that TSH, FT3 and FT4 assays may not be insufficient to detect long lasting peripheral effects of the thyroid hormones action. Further studies are needed to clarify whether and to what extent the evaluation of metabolomics profile may provide relevant information in the clinical management of hyperthyroidism." @default.
• W2742767384 created "2017-08-17" @default.
• W2742767384 creator A5002397695 @default.
• W2742767384 creator A5012861031 @default.
• W2742767384 creator A5045411761 @default.
• W2742767384 creator A5073333845 @default.
• W2742767384 creator A5079358204 @default.
• W2742767384 creator A5079887704 @default.
• W2742767384 date "2017-12-01" @default.
• W2742767384 modified "2023-10-17" @default.
• W2742767384 title "Metabolomic profile in hyperthyroid patients before and after antithyroid drug treatment: Correlation with thyroid hormone and TSH concentration" @default.
• W2742767384 cites W113507905 @default.
• W2742767384 cites W1480325895 @default.
• W2742767384 cites W1566039965 @default.
• W2742767384 cites W1975552865 @default.
• W2742767384 cites W1981659420 @default.
• W2742767384 cites W1992483596 @default.
• W2742767384 cites W1999469695 @default.
• W2742767384 cites W2011275871 @default.
• W2742767384 cites W2012060810 @default.
• W2742767384 cites W2015585621 @default.
• W2742767384 cites W2016021698 @default.
• W2742767384 cites W2019591658 @default.
• W2742767384 cites W2020720070 @default.
• W2742767384 cites W2021620963 @default.
• W2742767384 cites W2021932599 @default.
• W2742767384 cites W2022349101 @default.
• W2742767384 cites W2025565973 @default.
• W2742767384 cites W2028480431 @default.
• W2742767384 cites W2045074061 @default.
• W2742767384 cites W2046726596 @default.
• W2742767384 cites W2048328229 @default.
• W2742767384 cites W2048947192 @default.
• W2742767384 cites W2049667810 @default.
• W2742767384 cites W2060813749 @default.
• W2742767384 cites W2061919299 @default.
• W2742767384 cites W2069340792 @default.
• W2742767384 cites W2072303948 @default.
• W2742767384 cites W2077055938 @default.
• W2742767384 cites W2080884925 @default.
• W2742767384 cites W2082573418 @default.
• W2742767384 cites W2089210920 @default.
• W2742767384 cites W2114588377 @default.
• W2742767384 cites W2129816036 @default.
• W2742767384 cites W2168526937 @default.
• W2742767384 cites W2486134581 @default.
• W2742767384 cites W2520222164 @default.
• W2742767384 cites W2570498978 @default.
• W2742767384 cites W2763148304 @default.
• W2742767384 cites W3143189517 @default.
• W2742767384 cites W4238372547 @default.
• W2742767384 doi "https://doi.org/10.1016/j.biocel.2017.07.024" @default.
• W2742767384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28782601" @default.
• W2742767384 hasPublicationYear "2017" @default.
• W2742767384 type Work @default.
• W2742767384 sameAs 2742767384 @default.
• W2742767384 citedByCount "19" @default.
• W2742767384 countsByYear W27427673842017 @default.
• W2742767384 countsByYear W27427673842018 @default.
• W2742767384 countsByYear W27427673842019 @default.
• W2742767384 countsByYear W27427673842020 @default.
• W2742767384 countsByYear W27427673842021 @default.
• W2742767384 countsByYear W27427673842022 @default.
• W2742767384 countsByYear W27427673842023 @default.
• W2742767384 crossrefType "journal-article" @default.
• W2742767384 hasAuthorship W2742767384A5002397695 @default.
• W2742767384 hasAuthorship W2742767384A5012861031 @default.
• W2742767384 hasAuthorship W2742767384A5045411761 @default.
• W2742767384 hasAuthorship W2742767384A5073333845 @default.
• W2742767384 hasAuthorship W2742767384A5079358204 @default.
• W2742767384 hasAuthorship W2742767384A5079887704 @default.
• W2742767384 hasConcept C126322002 @default.
• W2742767384 hasConcept C134018914 @default.
• W2742767384 hasConcept C185592680 @default.
• W2742767384 hasConcept C188816634 @default.
• W2742767384 hasConcept C21565614 @default.
• W2742767384 hasConcept C2777195454 @default.
• W2742767384 hasConcept C43617362 @default.
• W2742767384 hasConcept C526584372 @default.
• W2742767384 hasConcept C71315377 @default.
• W2742767384 hasConcept C71924100 @default.
• W2742767384 hasConceptScore W2742767384C126322002 @default.
• W2742767384 hasConceptScore W2742767384C134018914 @default.
• W2742767384 hasConceptScore W2742767384C185592680 @default.
• W2742767384 hasConceptScore W2742767384C188816634 @default.
• W2742767384 hasConceptScore W2742767384C21565614 @default.
• W2742767384 hasConceptScore W2742767384C2777195454 @default.
• W2742767384 hasConceptScore W2742767384C43617362 @default.
• W2742767384 hasConceptScore W2742767384C526584372 @default.
• W2742767384 hasConceptScore W2742767384C71315377 @default.
• W2742767384 hasConceptScore W2742767384C71924100 @default.
• W2742767384 hasLocation W27427673841 @default.
• W2742767384 hasLocation W27427673842 @default.
• W2742767384 hasOpenAccess W2742767384 @default.
• W2742767384 hasPrimaryLocation W27427673841 @default.
• W2742767384 hasRelatedWork W165683302 @default.
• W2742767384 hasRelatedWork W2136863520 @default.
• W2742767384 hasRelatedWork W2141010084 @default.

• next