FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2742783609> ?p ?o ?g. }

• W2742783609 endingPage "27461" @default.
• W2742783609 startingPage "27453" @default.
• W2742783609 abstract "Zn biomaterials attract strong attentions recently for load-bearing medical implants because of their mechanical properties similar to bone, biocompatibility, and degradability at a more matched rate to tissue healing. It has been shown previously that Zn alloys are beneficial for bone regeneration, but the supporting mechanisms have not been explored in detail. Here, we studied the biological responses of human bone marrow mesenchymal stem cells (hMSC) to Zn and the underlying cellular signaling mechanisms. Typical Mg material AZ31 was used as a comparative benchmark control. Direct culture of cells on the materials revealed that cell adhesion, proliferation, and motility were higher on Zn than on AZ31. Significant cytoskeletal reorganizations induced by Zn or AZ31 were also observed. Mineralization of extracellular matrix (ECM) and hMSC osteogenic differentiation, measured by Alizarin red and ALP staining and activities, were significantly enhanced when cells were cultured with Zn or AZ31. Quantitative PCR also showed the increased expression of bone-related genes including ALP, collagen I, and osteopontin. Using small RNA interference to knockdown related key molecules, we illustrated the mechanisms of Zn-induced cellular signaling. TRPM7 and GPR39 appear to be the major cellular receptors facilitating Zn2+-entry into hMSC. The intracellular Zn2+ then activates the cAMP-PKA pathway and triggers intracellular Ca2+ responses, leading to activation of MAPK. In addition, Zn2+ activates the Gαq-PLC-AKT pathway as well. Eventually, all of this signaling would lead to enhanced differential regulation of genes, cell survival/growth and differentiation, ECM mineralization, osteogenesis, and other cellular activities." @default.
• W2742783609 created "2017-08-17" @default.
• W2742783609 creator A5000863621 @default.
• W2742783609 creator A5016856595 @default.
• W2742783609 creator A5021149882 @default.
• W2742783609 creator A5039695062 @default.
• W2742783609 creator A5045923205 @default.
• W2742783609 creator A5049943833 @default.
• W2742783609 date "2017-08-08" @default.
• W2742783609 modified "2023-10-16" @default.
• W2742783609 title "Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials" @default.
• W2742783609 cites W1038481661 @default.
• W2742783609 cites W106711231 @default.
• W2742783609 cites W1500220560 @default.
• W2742783609 cites W1970271735 @default.
• W2742783609 cites W1975682654 @default.
• W2742783609 cites W1976176247 @default.
• W2742783609 cites W1990190218 @default.
• W2742783609 cites W1994243327 @default.
• W2742783609 cites W2028719771 @default.
• W2742783609 cites W2029900752 @default.
• W2742783609 cites W2030015263 @default.
• W2742783609 cites W2040235837 @default.
• W2742783609 cites W2040439855 @default.
• W2742783609 cites W2045636109 @default.
• W2742783609 cites W2057700073 @default.
• W2742783609 cites W2082641885 @default.
• W2742783609 cites W2084572631 @default.
• W2742783609 cites W2094893662 @default.
• W2742783609 cites W2096735953 @default.
• W2742783609 cites W2113187147 @default.
• W2742783609 cites W2127642119 @default.
• W2742783609 cites W2136538328 @default.
• W2742783609 cites W2164258188 @default.
• W2742783609 cites W2185555832 @default.
• W2742783609 cites W2198176634 @default.
• W2742783609 cites W2208629799 @default.
• W2742783609 cites W2297102637 @default.
• W2742783609 cites W2413259836 @default.
• W2742783609 cites W2419281492 @default.
• W2742783609 cites W2510993966 @default.
• W2742783609 cites W2513253380 @default.
• W2742783609 cites W2552858482 @default.
• W2742783609 cites W4211147970 @default.
• W2742783609 cites W932876511 @default.
• W2742783609 doi "https://doi.org/10.1021/acsami.7b06654" @default.
• W2742783609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787130" @default.
• W2742783609 hasPublicationYear "2017" @default.
• W2742783609 type Work @default.
• W2742783609 sameAs 2742783609 @default.
• W2742783609 citedByCount "148" @default.
• W2742783609 countsByYear W27427836092017 @default.
• W2742783609 countsByYear W27427836092018 @default.
• W2742783609 countsByYear W27427836092019 @default.
• W2742783609 countsByYear W27427836092020 @default.
• W2742783609 countsByYear W27427836092021 @default.
• W2742783609 countsByYear W27427836092022 @default.
• W2742783609 countsByYear W27427836092023 @default.
• W2742783609 crossrefType "journal-article" @default.
• W2742783609 hasAuthorship W2742783609A5000863621 @default.
• W2742783609 hasAuthorship W2742783609A5016856595 @default.
• W2742783609 hasAuthorship W2742783609A5021149882 @default.
• W2742783609 hasAuthorship W2742783609A5039695062 @default.
• W2742783609 hasAuthorship W2742783609A5045923205 @default.
• W2742783609 hasAuthorship W2742783609A5049943833 @default.
• W2742783609 hasConcept C104317684 @default.
• W2742783609 hasConcept C148738053 @default.
• W2742783609 hasConcept C1491633281 @default.
• W2742783609 hasConcept C150555746 @default.
• W2742783609 hasConcept C189165786 @default.
• W2742783609 hasConcept C191897082 @default.
• W2742783609 hasConcept C192562407 @default.
• W2742783609 hasConcept C198826908 @default.
• W2742783609 hasConcept C203014093 @default.
• W2742783609 hasConcept C2777230088 @default.
• W2742783609 hasConcept C2780804394 @default.
• W2742783609 hasConcept C55493867 @default.
• W2742783609 hasConcept C62478195 @default.
• W2742783609 hasConcept C85789140 @default.
• W2742783609 hasConcept C86554907 @default.
• W2742783609 hasConcept C86803240 @default.
• W2742783609 hasConcept C95444343 @default.
• W2742783609 hasConceptScore W2742783609C104317684 @default.
• W2742783609 hasConceptScore W2742783609C148738053 @default.
• W2742783609 hasConceptScore W2742783609C1491633281 @default.
• W2742783609 hasConceptScore W2742783609C150555746 @default.
• W2742783609 hasConceptScore W2742783609C189165786 @default.
• W2742783609 hasConceptScore W2742783609C191897082 @default.
• W2742783609 hasConceptScore W2742783609C192562407 @default.
• W2742783609 hasConceptScore W2742783609C198826908 @default.
• W2742783609 hasConceptScore W2742783609C203014093 @default.
• W2742783609 hasConceptScore W2742783609C2777230088 @default.
• W2742783609 hasConceptScore W2742783609C2780804394 @default.
• W2742783609 hasConceptScore W2742783609C55493867 @default.
• W2742783609 hasConceptScore W2742783609C62478195 @default.
• W2742783609 hasConceptScore W2742783609C85789140 @default.
• W2742783609 hasConceptScore W2742783609C86554907 @default.
• W2742783609 hasConceptScore W2742783609C86803240 @default.

• next