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• W2742861490 startingPage "2" @default.
• W2742861490 abstract "Across the expanse of vertebrate evolution, each species produces multiple forms of hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple hemoglobins are encoded in two globin gene clusters in almost all species. One globin gene cluster, linked to the gene NPRL3, is preserved in all vertebrates, including a gene cluster encoding the highly divergent globins from jawless vertebrates. This preservation of synteny may reflect the presence of a powerful enhancer of globin gene expression in the NPRL3 gene. Despite substantial divergence in noncoding DNA sequences among mammals, several epigenetic features of the globin gene regulatory regions are preserved across vertebrates. The preserved features include multiple DNase hypersensitive sites, at least one of which is an enhancer, and binding by key lineage-restricted transcription factors such as GATA1 and TAL1, which in turn recruit coactivators such as P300 that catalyze acetylation of histones. The maps of epigenetic features are strongly correlated with activity in gene regulation, and resources for accessing and visualizing such maps are readily available to the community of researchers and students." @default.
• W2742861490 created "2017-08-17" @default.
• W2742861490 creator A5036074664 @default.
• W2742861490 creator A5069366964 @default.
• W2742861490 date "2018-05-01" @default.
• W2742861490 modified "2023-10-17" @default.
• W2742861490 title "Evolution of hemoglobin loci and their regulatory elements" @default.
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