FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743001412> ?p ?o ?g. }

• W2743001412 abstract "ABSTRACT Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, the Marseilleviridae is a well-recognized family because of its genomic mosaicism. The marseilleviruses have an ability to incorporate foreign genes, especially from sympatric organisms inhabiting Acanthamoeba , its main known host. Here, we identified for the first time an eight-nucleotide A/T-rich promoter sequence (AAATATTT) associated with 55% of marseillevirus genes that is conserved in all marseilleviruses lineages, a higher level of conservation than that of any giant virus described to date. We instigated our prediction about the promoter motif by biological assays and by evaluating how single mutations in this octamer can impact gene expression. The investigation of sequences that regulate the expression of genes relative to lateral transfer revealed that the promoter motifs do not appear to be incorporated by marseilleviruses from donor organisms. Indeed, analyses of the intergenic regions that regulate lateral gene transfer-related genes have revealed an independent origin of the marseillevirus intergenic regions that does not match gene-donor organisms. About 50% of AAATATTT motifs spread throughout intergenic regions of the marseilleviruses are present as multiple copies. We believe that such multiple motifs are associated with increased expression of a given gene or are related to incorporation of foreign genes into the mosaic genome of marseilleviruses. IMPORTANCE The marseilleviruses draw attention because of the peculiar features of their genomes; however, little is known about their gene expression patterns or the factors that regulate those expression patterns. The limited published research on the expression patterns of the marseilleviruses and their unique genomes has led us to study the promoter motif sequences in the intergenic regions of the marseilleviruses. This work is the first to analyze promoter sequences in the genomes of the marseilleviruses. We also suggest a strong capacity to acquire foreign genes and to express those genes mediated by multiple copies of the promoter motifs available in intergenic regions. These findings contribute to an understanding of genomic expansion and plasticity observed in these giant viruses." @default.
• W2743001412 created "2017-08-17" @default.
• W2743001412 creator A5008473732 @default.
• W2743001412 creator A5023619971 @default.
• W2743001412 creator A5034147614 @default.
• W2743001412 creator A5034182491 @default.
• W2743001412 creator A5049025790 @default.
• W2743001412 creator A5056663199 @default.
• W2743001412 creator A5065207037 @default.
• W2743001412 creator A5068763159 @default.
• W2743001412 creator A5076280300 @default.
• W2743001412 creator A5081854597 @default.
• W2743001412 creator A5089304726 @default.
• W2743001412 date "2017-11-01" @default.
• W2743001412 modified "2023-09-26" @default.
• W2743001412 title "The Investigation of Promoter Sequences of Marseilleviruses Highlights a Remarkable Abundance of the AAATATTT Motif in Intergenic Regions" @default.
• W2743001412 cites W1483435905 @default.
• W2743001412 cites W1592870802 @default.
• W2743001412 cites W1974451696 @default.
• W2743001412 cites W1977758308 @default.
• W2743001412 cites W1985588905 @default.
• W2743001412 cites W1994137684 @default.
• W2743001412 cites W2001394772 @default.
• W2743001412 cites W2007051444 @default.
• W2743001412 cites W2007093279 @default.
• W2743001412 cites W2011321416 @default.
• W2743001412 cites W2012116271 @default.
• W2743001412 cites W2026941435 @default.
• W2743001412 cites W2051262545 @default.
• W2743001412 cites W2058217073 @default.
• W2743001412 cites W2063872287 @default.
• W2743001412 cites W2067814503 @default.
• W2743001412 cites W2068118943 @default.
• W2743001412 cites W2068378652 @default.
• W2743001412 cites W2108702500 @default.
• W2743001412 cites W2123022761 @default.
• W2743001412 cites W2135090321 @default.
• W2743001412 cites W2149009996 @default.
• W2743001412 cites W2160034397 @default.
• W2743001412 cites W2162800068 @default.
• W2743001412 cites W2166413252 @default.
• W2743001412 cites W2170488656 @default.
• W2743001412 cites W2274378441 @default.
• W2743001412 cites W2293321240 @default.
• W2743001412 cites W2399866334 @default.
• W2743001412 cites W2495272815 @default.
• W2743001412 cites W2527652046 @default.
• W2743001412 cites W2556502686 @default.
• W2743001412 cites W2576746358 @default.
• W2743001412 cites W2606097554 @default.
• W2743001412 cites W4293021495 @default.
• W2743001412 doi "https://doi.org/10.1128/jvi.01088-17" @default.
• W2743001412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5640848" @default.
• W2743001412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28794030" @default.
• W2743001412 hasPublicationYear "2017" @default.
• W2743001412 type Work @default.
• W2743001412 sameAs 2743001412 @default.
• W2743001412 citedByCount "13" @default.
• W2743001412 countsByYear W27430014122018 @default.
• W2743001412 countsByYear W27430014122019 @default.
• W2743001412 countsByYear W27430014122020 @default.
• W2743001412 countsByYear W27430014122021 @default.
• W2743001412 countsByYear W27430014122022 @default.
• W2743001412 crossrefType "journal-article" @default.
• W2743001412 hasAuthorship W2743001412A5008473732 @default.
• W2743001412 hasAuthorship W2743001412A5023619971 @default.
• W2743001412 hasAuthorship W2743001412A5034147614 @default.
• W2743001412 hasAuthorship W2743001412A5034182491 @default.
• W2743001412 hasAuthorship W2743001412A5049025790 @default.
• W2743001412 hasAuthorship W2743001412A5056663199 @default.
• W2743001412 hasAuthorship W2743001412A5065207037 @default.
• W2743001412 hasAuthorship W2743001412A5068763159 @default.
• W2743001412 hasAuthorship W2743001412A5076280300 @default.
• W2743001412 hasAuthorship W2743001412A5081854597 @default.
• W2743001412 hasAuthorship W2743001412A5089304726 @default.
• W2743001412 hasBestOaLocation W27430014121 @default.
• W2743001412 hasConcept C101762097 @default.
• W2743001412 hasConcept C104317684 @default.
• W2743001412 hasConcept C117745874 @default.
• W2743001412 hasConcept C141231307 @default.
• W2743001412 hasConcept C150194340 @default.
• W2743001412 hasConcept C165864922 @default.
• W2743001412 hasConcept C167625842 @default.
• W2743001412 hasConcept C195139083 @default.
• W2743001412 hasConcept C199216141 @default.
• W2743001412 hasConcept C21592294 @default.
• W2743001412 hasConcept C54355233 @default.
• W2743001412 hasConcept C86803240 @default.
• W2743001412 hasConceptScore W2743001412C101762097 @default.
• W2743001412 hasConceptScore W2743001412C104317684 @default.
• W2743001412 hasConceptScore W2743001412C117745874 @default.
• W2743001412 hasConceptScore W2743001412C141231307 @default.
• W2743001412 hasConceptScore W2743001412C150194340 @default.
• W2743001412 hasConceptScore W2743001412C165864922 @default.
• W2743001412 hasConceptScore W2743001412C167625842 @default.
• W2743001412 hasConceptScore W2743001412C195139083 @default.
• W2743001412 hasConceptScore W2743001412C199216141 @default.
• W2743001412 hasConceptScore W2743001412C21592294 @default.
• W2743001412 hasConceptScore W2743001412C54355233 @default.
• W2743001412 hasConceptScore W2743001412C86803240 @default.

• next