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• W2743005637 abstract "CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or plasmids. The threat from mobile genetic elements inevitably shapes the CRISPR loci of archaea and bacteria, and simultaneously the CRISPR-Cas immune system drives evolution of these invaders. Here, we highlight our recent work, as well as that of others, that seeks to understand phage mechanisms of CRISPR-Cas evasion and conditions for population coexistence of phages with CRISPR-protected prokaryotes." @default.
• W2743005637 created "2017-08-17" @default.
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• W2743005637 creator A5051587395 @default.
• W2743005637 date "2017-01-01" @default.
• W2743005637 modified "2023-09-27" @default.
• W2743005637 title "How the Other Half Lives: CRISPR-Cas’s Influence on Bacteriophages" @default.
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• W2743005637 doi "https://doi.org/10.1007/978-3-319-61569-1_4" @default.
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