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• W2743008942 abstract "Novel methods to improve the anticancer performance of 5-fluorouracil (5-FU) is quite necessary for clinical medicines. In the present work, we fabricated a novel type of mesoporous silica nanoparticles (MSNs)-based inorganic/organic hybrid nanoparticles covalently attached with poly(oligo(ethylene glycol) monomethyl ether methacrylate) (POEGMA) for improved stabilization and targeting peptide (RGD) for targeted delivery with the aim of improving the anticancer performance of 5-FU. Atom transfer radical polymerization (ATRP) initiator functionalized MSN (MSN-Br) was synthesized at first, which was followed by surface-initiated ATRP of water soluble OEGMA and carboxyl-containing monomer (2-succinyloxyethyl methacrylate, SEMA). Functionalization of RGD onto the hydrophilic P(OEGMA-co-SEMA) chains afforded the final hybrid nanoparticle, MSN-P(OEGMA-co-RGD). 5-FU can be effectively loaded into the meso-pores of MSN-P(OEGMA-co-RGD) ([email protected]) with drug content ∼7.5 wt%. And the dynamic diameter (Dh) and zeta potential (ζ) of [email protected] were determined to be 199.3 ± 5.4 nm and −8.7 ± 0.5 mV, respectively. It was demonstrated that MSN-P(OEGMA-co-RGD) exhibited improved internalization into colon cancer cells and enhanced accumulation in tumor tissues. In addition, compared with free 5-FU, [email protected] showed enhanced anticancer efficacy both in vitro and in vivo, implying promising clinical applications." @default.
• W2743008942 created "2017-08-17" @default.
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• W2743008942 date "2017-11-01" @default.
• W2743008942 modified "2023-09-26" @default.
• W2743008942 title "Mesoporous silica nanoparticles (MSNs)-based organic/inorganic hybrid nanocarriers loading 5-Fluorouracil for the treatment of colon cancer with improved anticancer efficacy" @default.
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• W2743008942 doi "https://doi.org/10.1016/j.colsurfb.2017.08.013" @default.
• W2743008942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28818782" @default.
• W2743008942 hasPublicationYear "2017" @default.
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