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• W2743018412 abstract "Programs of gene expression are executed by a battery of transcription factors that coordinate divergent transcription from a pair of tightly linked core initiation regions of promoters and enhancers. Here, to investigate how divergent transcription is reprogrammed upon stress, we measured nascent RNA synthesis at nucleotide-resolution, and profiled histone H4 acetylation in human cells. Our results globally show that the release of promoter-proximal paused RNA polymerase into elongation functions as a critical switch at which a gene's response to stress is determined. Highly transcribed and highly inducible genes display strong transcriptional directionality and selective assembly of general transcription factors on the core sense promoter. Heat-induced transcription at enhancers, instead, correlates with prior binding of cell-type, sequence-specific transcription factors. Activated Heat Shock Factor 1 (HSF1) binds to transcription-primed promoters and enhancers, and CTCF-occupied, non-transcribed chromatin. These results reveal chromatin architectural features that orient transcription at divergent regulatory elements and prime transcriptional responses genome-wide.Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, untranscribed chromatin." @default.
• W2743018412 created "2017-08-17" @default.
• W2743018412 creator A5001720782 @default.
• W2743018412 creator A5007027974 @default.
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• W2743018412 creator A5035778992 @default.
• W2743018412 creator A5056279051 @default.
• W2743018412 creator A5060183257 @default.
• W2743018412 date "2017-08-15" @default.
• W2743018412 modified "2023-10-14" @default.
• W2743018412 title "Transcriptional response to stress is pre-wired by promoter and enhancer architecture" @default.
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• W2743018412 doi "https://doi.org/10.1038/s41467-017-00151-0" @default.
• W2743018412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5557961" @default.
• W2743018412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28811569" @default.
• W2743018412 hasPublicationYear "2017" @default.
• W2743018412 type Work @default.
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