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- W2743028812 abstract "Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly understood. Here, we used an experimental model that reproduces olanzapine-induced hyperphagia and obesity in female C57BL/6 mice. We found that olanzapine treatment acutely increased food intake, impaired glucose tolerance, and altered physical activity and energy expenditure in mice. Furthermore, olanzapine-induced hyperphagia and weight gain were blunted in mice lacking the serotonin 2C receptor (HTR2C). Finally, we showed that treatment with the HTR2C-specific agonist lorcaserin suppressed olanzapine-induced hyperphagia and weight gain. Lorcaserin treatment also improved glucose tolerance in olanzapine-fed mice. Collectively, our studies suggest that olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C." @default.
- W2743028812 created "2017-08-17" @default.
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- W2743028812 date "2017-08-14" @default.
- W2743028812 modified "2023-10-16" @default.
- W2743028812 title "The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C" @default.
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- W2743028812 doi "https://doi.org/10.1172/jci93362" @default.
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