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- W2743115422 abstract "Mitochondria are like miniature fortresses. Getting synthetic chemicals past this organelle’s formidable double membrane isn’t easy. As a result, scientists haven’t yet developed drugs that target the biology underlying mitochondrial disorders, which can be deadly. Now, researchers have developed a peptidelike molecule that penetrates the mitochondrial membrane to inhibit the expression of a gene associated with nerve and muscle diseases (J. Am. Chem. Soc. 2017, DOI: 10.1021/jacs.7b05230). In the past couple of decades, scientists have developed compounds called pyrrole-imidazole polyamides (PIPs) to modify gene expression in cells. These peptidelike polymers consist of nonnatural amino acids with pyrrole or imidazole rings. Researchers can use PIPs as a tool for silencing genes by designing the sequence of amino acids to target and bind to specific stretches of DNA. When such agents target the promoter region of a gene, they block a transcription factor from binding and starting gene expression. Ganesh N. Pandian" @default.
- W2743115422 created "2017-08-17" @default.
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- W2743115422 date "2017-07-24" @default.
- W2743115422 modified "2023-09-27" @default.
- W2743115422 title "Designer molecule silences mitochondrial genes" @default.
- W2743115422 doi "https://doi.org/10.1021/cen-09530-notw6" @default.
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