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• W2743115961 abstract "The application of a self-assembling peptide on noncavitated caries lesions is supposed to be a feasible approach to facilitate remineralization and mask their unfavorable appearance. However, demineralizing conditions are common in the oral environment, so the aim of this pH-cycling study was to compare recommended and novel treatment methods regarding their ability to hamper demineralization and as a consequence mask artificial enamel caries lesions. Artificial caries lesions were prepared in bovine enamel and randomly allocated to 11 groups (<i>n</i> = 22). Treatments before pH-cycling were as follows: the application of a self-assembling peptide (Curodont™ Repair [C]), a low-viscosity resin (Icon® [I]), 2 fluoride solutions (10,000 ppm F^-: Elmex fluid [E] and 43,350 ppm F^-: Tiefenfluorid® [T]), and no intervention (N). During pH-cycling (28 days, 6 × 60 min demineralization/day) half of the specimens in each group were brushed (10 s; 2 ×/day) with either fluoride-free (named e.g., C₀) or NaF (1,100 ppm F^-; e.g., C₁) dentifrice slurry. In another subgroup specimens were pH-cycled but not brushed (N_NB). Differences in integrated mineral loss (&#x0394;&#x0394;Z), lesion depth (&#x0394;LD), and colorimetric values (&#x0394;&#x0394;E) were calculated between values after pre-demineralization, surface treatment, and pH-cycling. Specimens of C₀, C₁, N_NB, N₀, N₁, T₀, and E₀ showed significantly increased &#x0394;Z and LD values after pH-cycling (<i>p</i> ≤ 0.003; paired <i>t</i> test). C₀, C₁, N_NB, and N₀ showed significantly higher changes in &#x0394;&#x0394;Z than E₁, I₀, I₁, and T₁ (<i>p</i> < 0.001; ANOVA). Significantly reduced colorimetric values could only be observed for I₁, I₀, E₁, and E₀ after treatment and after pH-cycling (<i>p</i> ≤ 0.027; paired <i>t</i> test). In conclusion, under the conditions chosen only the application of a low-viscosity resin could mask caries lesions significantly, whereas self-assembling peptides could neither inhibit lesion progression nor mask the lesions considerably." @default.
• W2743115961 created "2017-08-17" @default.
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• W2743115961 date "2017-01-01" @default.
• W2743115961 modified "2023-10-14" @default.
• W2743115961 title "Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro" @default.
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• W2743115961 doi "https://doi.org/10.1159/000477215" @default.
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