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- W2743127963 abstract "We have previously reported on a novel mesh culture method that enables fabrication of standalone cell sheets that can be easily integrated with microfluidics to realize tissue-on-a-chip for in vitro studies [1]. Here we report on the fabrication of a bilayer tissue consisting of fibroblasts and HUVECs using a mesh culture approach which permits direct cross-layer cell-cell interaction and communication, unlike in existing co-culture systems where this is impeded by an interfacing substrate between the cell layers. We show that the direct cross-layer interaction induces fibrotic-like swelling of the fibroblast layer and micro-vessel formation by HUVECs. Thus, we present a model that can recapitulate the development of fibrosis, which is a disease condition affecting many organs in the body." @default.
- W2743127963 created "2017-08-17" @default.
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- W2743127963 date "2017-06-01" @default.
- W2743127963 modified "2023-10-03" @default.
- W2743127963 title "Toward fabrication of vascularized tissues using a bilayer co-culture approach achieved by a mesh culture technique" @default.
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- W2743127963 doi "https://doi.org/10.1109/transducers.2017.7994046" @default.
- W2743127963 hasPublicationYear "2017" @default.
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