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- W2743129631 abstract "Publisher Summary This chapter discusses whether, after intracerebroventricular (i.c.v.) application, peptides may exert a cumulative effect on the passive avoidance reaction of the rat. In numerous publications, neuroactive peptides have been reported to occur in the cerebrospinal fluid (CSF), even though the concentrations found are comparatively low. Neuroactive peptides applied to the CSF system of experimental animals influence the behavior; still, usually a dose had to be applied, which by far exceeded the concentration of the natural occurrence. For example, i.c.v. injections of 1 ng and 10 ng vasopressin or oxytocin caused statistically significant changes in the passive and active avoidance reaction of the rat, with the two peptides entailing opposite effects throughout. In view of the discrepancy between the concentrations at which the peptides usually occur in the CSF and those to be applied in experiments, it might be concluded that the functional relevance of the peptides in the CSF is of only minor importance to neuronal regulation processes." @default.
- W2743129631 created "2017-08-17" @default.
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- W2743129631 date "1992-01-01" @default.
- W2743129631 modified "2023-09-24" @default.
- W2743129631 title "Chapter 60: Neuropeptides in the cerebrospinal fluid and regulation of behavior" @default.
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- W2743129631 doi "https://doi.org/10.1016/s0079-6123(08)62367-5" @default.
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