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• W2743135312 endingPage "e0181886" @default.
• W2743135312 startingPage "e0181886" @default.
• W2743135312 abstract "Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. First, we showed that approximately two-thirds and one-third of the trimers secreted from the ChAdOx1.BG505s (C) and MVA.BG505s (M) vaccine-infected cells, respectively, were cleaved and in a native-like conformation. Rabbits were immunized intramuscularly with these vaccine vectors and in some cases boosted with ISCOMATRIX™-adjuvanted BG505s protein trimer (P), using CCC, MMM, PPP, CPP, MPP and CMP vaccine regimens. We found that the peak trimer-binding antibody and tier-1A and autologous tier-2 nAb responses induced by the CC, CM, PPP, CPP, MPP and CMP regimens were comparable, although only PPP induced autologous tier-2 nAbs in all the immunized animals. Three animals developed weak heterologous tier-2 nAbs. These results demonstrate that ChAdOx1 and MVA vectors are useful delivery modalities for not only T-cell, but also antibody vaccine development." @default.
• W2743135312 created "2017-08-17" @default.
• W2743135312 creator A5004036928 @default.
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• W2743135312 date "2017-08-09" @default.
• W2743135312 modified "2023-10-16" @default.
• W2743135312 title "HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers" @default.
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• W2743135312 doi "https://doi.org/10.1371/journal.pone.0181886" @default.
• W2743135312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5549892" @default.
• W2743135312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28792942" @default.
• W2743135312 hasPublicationYear "2017" @default.
• W2743135312 type Work @default.
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• W2743135312 citedByCount "15" @default.
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• W2743135312 hasAuthorship W2743135312A5004036928 @default.
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