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• W274313708 abstract "Phosphatidylcholine (PtdCho) can provide lipid second messengers involved in signal transduction pathways. As a measure of phospholipid turnover in response to extracellular stimulation, we investigated differential enhancement of [3H]choline incorporation into PtdCho by phorbol esters. In C6 rat glioma and SK-N-SH human neuroblastoma cells, [3H]PtdCho synthesis was 24 fold stimulated by [3-12-O-tetradecanoylphorbol-13-acetate ([3-TPA) when [3H]choline was incubated simultaneously with, or 15 min prior to, [3-TPA treatment. By contrast, in N1E-115 mouse and SK-N-MC human neuroblastoma cells, phorbol esters had no appreciable effect on [3H]choline incorporation; however, in all cells, 200 gM oleic acid enhanced PtdCho synthesis, indicating a stimulable process. Alterations by thymeleatoxin (TMT), an activator of conventional PKC isoforms (% [3 and ~), were similar to [3-TPA. We investigated whether expression of specific PKC isoforms might correlate with these effects of phorbol esters on PtdCho synthesis. All cell lines bound phorbol esters, had PKC activity that was translocated by phorbol esters and differentially expressed isoforms of PKC. Northern and western blot analyses, using specific eDNA and antibodies for PKC-c~, -[3, -% -8, -~, and -~, revealed that expression of ~-isoform predominated in C6 and SK-N-SH cells. In contrast, TPA-responsive [3-isoform predominated in SK-N-MC cells. -y-PKC was not detected in any cells and only in C6 cells was PKC-g present and transtocated by [3-TPA treatment. PKC-e was not detected in SK-N-MC cell lines but translocated with TPA treatment in the other three cell lines. PKC-~ was present in all cells but was unaltered by TPA treatment. Accordingly, stimulation of PtdCho turnover by phorbol esters correlated only with expression of PKC-c~; presence of PKC-[3 alone was insufficient for a TPA response." @default.
• W274313708 created "2016-06-24" @default.
• W274313708 creator A5017469575 @default.
• W274313708 creator A5051551911 @default.
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• W274313708 creator A5074032583 @default.
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• W274313708 date "1995-01-01" @default.
• W274313708 modified "2023-09-27" @default.
• W274313708 title "Phorbol Ester Stimulation of Phosphatidylcholine in Four Cultured Neural Cell Lines: Correlations Expression of Protein Kinase C Isoforms Synthesis with" @default.
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• W274313708 hasPublicationYear "1995" @default.
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