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• W2743144033 endingPage "80" @default.
• W2743144033 startingPage "69" @default.
• W2743144033 abstract "Sites and mechanisms by which trigeminal nerve stimulation (TNS) exerts beneficial effects on symptoms of drug-resistant epilepsy and depression are still unknown. Effects of short-term TNS on brain regions involved in the physiopathology of these disorders were investigated in this study. Forty male rats were assigned to three groups: TNS (undergoing electrical stimulation of the left infraorbitary nerve via surgically implanted cuff electrodes); Sham (undergoing surgical procedure but without a stimulation); Naïve rats. The effects of TNS (3-hour session; 30-s ON, 5-min OFF; 30 Hz; 500 μs; 2 mA) were evaluated on: (i) behavioral pattern of pentylenetetrazole (PTZ)-induced seizures as measured by the Racine scale; (ii) c-Fos-like immunoreactivity in discrete brain areas; (iii) hippocampal cell proliferation by bromodeoxyuridine (BrdU)-like immunoreactivity. In comparison with Sham groups, TNS significantly decreased the duration of PTZ-induced seizures (p < 0.05) and promoted a faster recovery (p < 0.001) by reducing the most severe seizure types. In the TNS group the number of c-Fos-labeled cells was significantly increased (p < 0.001) in the trigeminal nuclear complex, nucleus of the solitary tract, locus coeruleus, dorsal raphe nucleus, hippocampus, amygdala, endopiriform nucleus, entorhinal cortex and sensorimotor cortex. In the TNS group the number of BrdU-positive cells in the dentate gyrus was significantly greater with respect to both Naïve and Sham groups. Data show that acute TNS effectively counteracted PTZ-induced seizures and boosted hippocampal cell proliferation in rats. TNS increased c-Fos-like immunoreactivity in brainstem and forebrain structures which play a pivotal role in the physiopathology of epilepsy and depression." @default.
• W2743144033 created "2017-08-17" @default.
• W2743144033 creator A5005400684 @default.
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• W2743144033 creator A5089716389 @default.
• W2743144033 date "2017-10-01" @default.
• W2743144033 modified "2023-10-15" @default.
• W2743144033 title "Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats" @default.
• W2743144033 cites W1015713818 @default.
• W2743144033 cites W1192784695 @default.
• W2743144033 cites W1498647569 @default.
• W2743144033 cites W1518090354 @default.
• W2743144033 cites W1553486550 @default.
• W2743144033 cites W1577226315 @default.
• W2743144033 cites W1578980117 @default.
• W2743144033 cites W1923393244 @default.
• W2743144033 cites W1970089573 @default.
• W2743144033 cites W1974799637 @default.
• W2743144033 cites W1976717011 @default.
• W2743144033 cites W1979904784 @default.
• W2743144033 cites W1979937204 @default.
• W2743144033 cites W1980606251 @default.
• W2743144033 cites W1985713532 @default.
• W2743144033 cites W1988152811 @default.
• W2743144033 cites W1989145429 @default.
• W2743144033 cites W1991148272 @default.
• W2743144033 cites W1991238949 @default.
• W2743144033 cites W1994514215 @default.
• W2743144033 cites W1995261715 @default.
• W2743144033 cites W2006586529 @default.
• W2743144033 cites W2011331569 @default.
• W2743144033 cites W2011830521 @default.
• W2743144033 cites W2015426483 @default.
• W2743144033 cites W2015772561 @default.
• W2743144033 cites W2017734759 @default.
• W2743144033 cites W2024689361 @default.
• W2743144033 cites W2026099701 @default.
• W2743144033 cites W2026720425 @default.
• W2743144033 cites W2028606712 @default.
• W2743144033 cites W2029048820 @default.
• W2743144033 cites W2030353885 @default.
• W2743144033 cites W2036832220 @default.
• W2743144033 cites W2039692499 @default.
• W2743144033 cites W2040492899 @default.
• W2743144033 cites W2042551807 @default.
• W2743144033 cites W2046101426 @default.
• W2743144033 cites W2049611124 @default.
• W2743144033 cites W2050148502 @default.
• W2743144033 cites W2052012507 @default.
• W2743144033 cites W2052594619 @default.
• W2743144033 cites W2058489875 @default.
• W2743144033 cites W2061266457 @default.
• W2743144033 cites W2062416577 @default.
• W2743144033 cites W2063164690 @default.
• W2743144033 cites W2063773170 @default.
• W2743144033 cites W2064175788 @default.
• W2743144033 cites W2064212430 @default.
• W2743144033 cites W2064445431 @default.
• W2743144033 cites W2065745057 @default.
• W2743144033 cites W2067099582 @default.
• W2743144033 cites W2068314862 @default.
• W2743144033 cites W2069737416 @default.
• W2743144033 cites W2074134542 @default.
• W2743144033 cites W2075657688 @default.
• W2743144033 cites W2076323101 @default.
• W2743144033 cites W2076432328 @default.
• W2743144033 cites W2078310235 @default.
• W2743144033 cites W2078790407 @default.
• W2743144033 cites W2078834347 @default.
• W2743144033 cites W2079370219 @default.
• W2743144033 cites W2080231242 @default.
• W2743144033 cites W2083974405 @default.
• W2743144033 cites W2085100394 @default.
• W2743144033 cites W2093225656 @default.
• W2743144033 cites W2097566284 @default.
• W2743144033 cites W2103946141 @default.
• W2743144033 cites W2108670804 @default.
• W2743144033 cites W2117811198 @default.
• W2743144033 cites W2118564947 @default.
• W2743144033 cites W2126282700 @default.
• W2743144033 cites W2128257083 @default.
• W2743144033 cites W2133565799 @default.
• W2743144033 cites W2138401704 @default.
• W2743144033 cites W2138728119 @default.
• W2743144033 cites W2145572652 @default.
• W2743144033 cites W2148239264 @default.
• W2743144033 cites W2154557118 @default.
• W2743144033 cites W2157595383 @default.
• W2743144033 cites W2272053455 @default.
• W2743144033 cites W2296702194 @default.
• W2743144033 cites W2600365015 @default.
• W2743144033 cites W4292167789 @default.
• W2743144033 doi "https://doi.org/10.1016/j.neuroscience.2017.08.012" @default.

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