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- W2743157212 abstract "ObjectiveTo explore the clinical characteristics, diagnosis, treatment and prognosis of EBV-associated central nervous system (CNS) diseases after allo-geneic hematopoietic stem cell transplantation (allo-HSCT).MethodsWe retrospectively analyzed the clinical data of 6 cases of EBV associated CNS diseases after allo-HSCT.ResultsSix patients undergoing sibling transplantation were diagnosed as having EBV-associated CNS diseases among 157 recipients. The median time of onset was (91.50±60.84) days (range: 52-206). The clinical symptoms had no specificity, including epilepsy, coma, pain and paralysis of the lower limbs, headache and hypertension. MRI scanning showed 4 patients had some lesions in cerebral hemispheres or spinal cord. EBV DNA was positive in cerebrospinal fluid (CSF) in 6 patients. Meanwhile only 1 case was positive in peripheral blood. After treatment with reduction or withdrawal of immunospressive agents, donor lymphocyte, intrathecal Rituximab and low dose donor lymphocyte, 4 cases were cured and 2 cases alive till now.ConclusionEarly diagnosis of EBV-associated CNS diseases depends on EBV DNA detection in CSF. Discrepancy in EBV DNA load between peripheral blood and CSF is presence in these patients. Severe aplastic anemia patients undergoing allo-HSCT are apt to involvement. Reduction or withdrawal of immunospressive agents, intrathecal Rituximab and low dose donor lymphocyte are effective treatment.Key words: Hematopoietic stem cell transplantation; Epstein-Barr virus; Central nervous system; Post-transplantation lymphoproliferative diseases" @default.
- W2743157212 created "2017-08-17" @default.
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- W2743157212 date "2016-08-20" @default.
- W2743157212 modified "2023-09-25" @default.
- W2743157212 title "Clinical research of EBV-associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation: six cases report and literature review" @default.
- W2743157212 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2016.08.007" @default.
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