FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743167573> ?p ?o ?g. }

• W2743167573 endingPage "1984" @default.
• W2743167573 startingPage "1974" @default.
• W2743167573 abstract "Immune checkpoint blockade is a promising anticancer therapy, but must be used in combination with other anticancer therapies to increase its therapeutic efficacy. Cyclophosphamide ( CP ) is a chemotherapeutic drug that shows immune‐modulating effects. In this study, we examined the effect of CP on anti‐ CTL ‐associated protein 4 ( CTLA ‐4) blockade therapy in two mouse tumor models. Drastic tumor regression was observed in the CT 26 colon carcinoma model after i.p. injection of CP (100 mg/kg) followed by anti‐ CTLA ‐4 antibody. However, administration in the reverse order increased apoptosis in tumor‐specific CD 8 + T cells. In the RENCA renal carcinoma model, the antitumor effect of combination therapy was marginal and the tumor‐bearing state reduced body weight with an increased serum level of interleukin‐6. Interestingly, although CP monotherapy increased myeloid‐derived suppressor cells ( MDSC s) in the spleens of both models, subsequent anti‐ CTLA ‐4 therapy increased MDSC s only in RENCA ‐bearing mice. Additionally, the serum levels of chemokine ligand 2 and C‐X‐C motif chemokine 10 were increased by the combination therapy only in RENCA ‐bearing mice and in vivo depletion of Gr‐1 + cells augmented the antitumor effect to some degree. These results reveal a contrasting effect of CP on anti‐ CTLA ‐4 therapy between the two mouse tumor models. Cyclophosphamide augments the antitumor effect of anti‐ CTLA ‐4 therapy in CT 26‐bearing hosts, whereas CP after anti‐ CTLA ‐4 therapy attenuates this effect through induction of apoptosis in tumor‐reactive T cells. Alternatively, CP ‐induced MDSC s can be increased by anti‐ CTLA ‐4 therapy only in RENCA ‐bearing hosts with an elevated level of interleukin‐6." @default.
• W2743167573 created "2017-08-17" @default.
• W2743167573 creator A5000210861 @default.
• W2743167573 creator A5000508958 @default.
• W2743167573 creator A5046680709 @default.
• W2743167573 creator A5071279215 @default.
• W2743167573 creator A5072733384 @default.
• W2743167573 creator A5085398424 @default.
• W2743167573 date "2017-08-29" @default.
• W2743167573 modified "2023-10-06" @default.
• W2743167573 title "Contrasting effects of cyclophosphamide on anti‐ <scp>CTL</scp> ‐associated protein 4 blockade therapy in two mouse tumor models" @default.
• W2743167573 cites W1455592191 @default.
• W2743167573 cites W1493925539 @default.
• W2743167573 cites W1521747187 @default.
• W2743167573 cites W1551688690 @default.
• W2743167573 cites W1654809115 @default.
• W2743167573 cites W1925817305 @default.
• W2743167573 cites W1974612137 @default.
• W2743167573 cites W1979235929 @default.
• W2743167573 cites W1994993231 @default.
• W2743167573 cites W2029320450 @default.
• W2743167573 cites W2033577259 @default.
• W2743167573 cites W2038381158 @default.
• W2743167573 cites W2052753304 @default.
• W2743167573 cites W2056969054 @default.
• W2743167573 cites W2060416134 @default.
• W2743167573 cites W2064084286 @default.
• W2743167573 cites W2079068389 @default.
• W2743167573 cites W2081796577 @default.
• W2743167573 cites W2094179246 @default.
• W2743167573 cites W2096322385 @default.
• W2743167573 cites W2097894274 @default.
• W2743167573 cites W2103707167 @default.
• W2743167573 cites W2104079620 @default.
• W2743167573 cites W2110440135 @default.
• W2743167573 cites W2111415894 @default.
• W2743167573 cites W2117985944 @default.
• W2743167573 cites W2120426523 @default.
• W2743167573 cites W2121314233 @default.
• W2743167573 cites W2132779216 @default.
• W2743167573 cites W2149118203 @default.
• W2743167573 cites W2149629545 @default.
• W2743167573 cites W2153725546 @default.
• W2743167573 cites W2154326457 @default.
• W2743167573 cites W2157269800 @default.
• W2743167573 cites W2162195553 @default.
• W2743167573 cites W2210453860 @default.
• W2743167573 cites W2252550602 @default.
• W2743167573 cites W2265285917 @default.
• W2743167573 cites W2275606382 @default.
• W2743167573 cites W2288921756 @default.
• W2743167573 cites W2340636398 @default.
• W2743167573 cites W2511743252 @default.
• W2743167573 cites W2567825448 @default.
• W2743167573 cites W2588975115 @default.
• W2743167573 cites W2593003512 @default.
• W2743167573 doi "https://doi.org/10.1111/cas.13337" @default.
• W2743167573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5623733" @default.
• W2743167573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787548" @default.
• W2743167573 hasPublicationYear "2017" @default.
• W2743167573 type Work @default.
• W2743167573 sameAs 2743167573 @default.
• W2743167573 citedByCount "32" @default.
• W2743167573 countsByYear W27431675732018 @default.
• W2743167573 countsByYear W27431675732019 @default.
• W2743167573 countsByYear W27431675732020 @default.
• W2743167573 countsByYear W27431675732021 @default.
• W2743167573 countsByYear W27431675732022 @default.
• W2743167573 countsByYear W27431675732023 @default.
• W2743167573 crossrefType "journal-article" @default.
• W2743167573 hasAuthorship W2743167573A5000210861 @default.
• W2743167573 hasAuthorship W2743167573A5000508958 @default.
• W2743167573 hasAuthorship W2743167573A5046680709 @default.
• W2743167573 hasAuthorship W2743167573A5071279215 @default.
• W2743167573 hasAuthorship W2743167573A5072733384 @default.
• W2743167573 hasAuthorship W2743167573A5085398424 @default.
• W2743167573 hasBestOaLocation W27431675731 @default.
• W2743167573 hasConcept C126322002 @default.
• W2743167573 hasConcept C13373296 @default.
• W2743167573 hasConcept C147969180 @default.
• W2743167573 hasConcept C150903083 @default.
• W2743167573 hasConcept C154317977 @default.
• W2743167573 hasConcept C167672396 @default.
• W2743167573 hasConcept C170493617 @default.
• W2743167573 hasConcept C185592680 @default.
• W2743167573 hasConcept C202751555 @default.
• W2743167573 hasConcept C203014093 @default.
• W2743167573 hasConcept C207001950 @default.
• W2743167573 hasConcept C2776694085 @default.
• W2743167573 hasConcept C2776755627 @default.
• W2743167573 hasConcept C2776999253 @default.
• W2743167573 hasConcept C2778468042 @default.
• W2743167573 hasConcept C502942594 @default.
• W2743167573 hasConcept C55493867 @default.
• W2743167573 hasConcept C71924100 @default.
• W2743167573 hasConcept C86803240 @default.
• W2743167573 hasConcept C8891405 @default.
• W2743167573 hasConcept C98274493 @default.

• next