Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743205823> ?p ?o ?g. }
- W2743205823 endingPage "735" @default.
- W2743205823 startingPage "723" @default.
- W2743205823 abstract "The receptor for epidermal growth factor (EGFR) is a prime target for cancer therapy across a broad variety of tumor types. As it is a tyrosine kinase, small molecule tyrosine kinase inhibitors (TKIs) targeting signal transduction, as well as monoclonal antibodies against the EGFR, have been investigated as anti-tumor agents. However, despite the long-known enigmatic EGFR gene amplification and protein overexpression in glioblastoma, the most aggressive intrinsic human brain tumor, the potential of EGFR as a target for this tumor type has been unfulfilled. This review analyses the attempts to use TKIs and monoclonal antibodies against glioblastoma, with special consideration given to immunological approaches, the use of EGFR as a docking molecule for conjugates with toxins, T-cells, oncolytic viruses, exosomes and nanoparticles. Drug delivery issues associated with therapies for intracerebral diseases, with specific emphasis on convection enhanced delivery, are also discussed." @default.
- W2743205823 created "2017-08-17" @default.
- W2743205823 creator A5017579441 @default.
- W2743205823 creator A5057284603 @default.
- W2743205823 creator A5064697931 @default.
- W2743205823 date "2017-08-08" @default.
- W2743205823 modified "2023-10-14" @default.
- W2743205823 title "EGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise" @default.
- W2743205823 cites W131042380 @default.
- W2743205823 cites W1470598344 @default.
- W2743205823 cites W1481410803 @default.
- W2743205823 cites W166159434 @default.
- W2743205823 cites W1803152299 @default.
- W2743205823 cites W1805464732 @default.
- W2743205823 cites W1831063376 @default.
- W2743205823 cites W1951559178 @default.
- W2743205823 cites W1963558982 @default.
- W2743205823 cites W1966803171 @default.
- W2743205823 cites W1967908989 @default.
- W2743205823 cites W1969731848 @default.
- W2743205823 cites W1973041517 @default.
- W2743205823 cites W1973071934 @default.
- W2743205823 cites W1974546646 @default.
- W2743205823 cites W1978118502 @default.
- W2743205823 cites W1978177843 @default.
- W2743205823 cites W1983343441 @default.
- W2743205823 cites W1987681742 @default.
- W2743205823 cites W1988658787 @default.
- W2743205823 cites W1989891384 @default.
- W2743205823 cites W1990736053 @default.
- W2743205823 cites W1995502732 @default.
- W2743205823 cites W1999526725 @default.
- W2743205823 cites W2002613111 @default.
- W2743205823 cites W2009063639 @default.
- W2743205823 cites W2009914447 @default.
- W2743205823 cites W2012334477 @default.
- W2743205823 cites W2013878898 @default.
- W2743205823 cites W2014485768 @default.
- W2743205823 cites W2014896274 @default.
- W2743205823 cites W2016568386 @default.
- W2743205823 cites W2019018696 @default.
- W2743205823 cites W2022920647 @default.
- W2743205823 cites W2024158973 @default.
- W2743205823 cites W2028009636 @default.
- W2743205823 cites W2030017878 @default.
- W2743205823 cites W2030393556 @default.
- W2743205823 cites W2034144674 @default.
- W2743205823 cites W2038657036 @default.
- W2743205823 cites W2040176056 @default.
- W2743205823 cites W2040220686 @default.
- W2743205823 cites W2048260140 @default.
- W2743205823 cites W2053655323 @default.
- W2743205823 cites W2054616560 @default.
- W2743205823 cites W2054727624 @default.
- W2743205823 cites W2056461634 @default.
- W2743205823 cites W2056679169 @default.
- W2743205823 cites W2061005093 @default.
- W2743205823 cites W2061760261 @default.
- W2743205823 cites W2066740999 @default.
- W2743205823 cites W2074885018 @default.
- W2743205823 cites W2077524564 @default.
- W2743205823 cites W2078085435 @default.
- W2743205823 cites W2078791896 @default.
- W2743205823 cites W2083172345 @default.
- W2743205823 cites W2084278966 @default.
- W2743205823 cites W2094817510 @default.
- W2743205823 cites W2095240672 @default.
- W2743205823 cites W2096287682 @default.
- W2743205823 cites W2099618978 @default.
- W2743205823 cites W2100265701 @default.
- W2743205823 cites W2100567246 @default.
- W2743205823 cites W2102626211 @default.
- W2743205823 cites W2104465685 @default.
- W2743205823 cites W2105879190 @default.
- W2743205823 cites W2107132417 @default.
- W2743205823 cites W2108623236 @default.
- W2743205823 cites W2109816625 @default.
- W2743205823 cites W2110966639 @default.
- W2743205823 cites W2111687371 @default.
- W2743205823 cites W2111718329 @default.
- W2743205823 cites W2112810120 @default.
- W2743205823 cites W2112887207 @default.
- W2743205823 cites W2118579930 @default.
- W2743205823 cites W2118925058 @default.
- W2743205823 cites W2121810724 @default.
- W2743205823 cites W2121889629 @default.
- W2743205823 cites W2122567785 @default.
- W2743205823 cites W2123610802 @default.
- W2743205823 cites W2126778627 @default.
- W2743205823 cites W2136295449 @default.
- W2743205823 cites W2136963436 @default.
- W2743205823 cites W2137261274 @default.
- W2743205823 cites W2137382956 @default.
- W2743205823 cites W2139004759 @default.
- W2743205823 cites W2139443474 @default.
- W2743205823 cites W2139923932 @default.
- W2743205823 cites W2144389809 @default.
- W2743205823 cites W2144909107 @default.