Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743208736> ?p ?o ?g. }
- W2743208736 endingPage "375" @default.
- W2743208736 startingPage "360" @default.
- W2743208736 abstract "Glutathione (GSH) is the major non-protein thiol in humans and other mammals, which is present in millimolar concentrations within cells, but at much lower concentrations in the blood plasma. GSH and GSH-related enzymes act both to prevent oxidative damage and to detoxify electrophiles. Under oxidative stress, two GSH molecules become linked by a disulphide bridge to form glutathione disulphide (GSSG). Therefore, assessment of the GSH/GSSG ratio may provide an estimation of cellular redox metabolism. Current evidence resulting from studies in human blood, solid tissues, and cultured cells suggests that GSH also plays a prominent role in protein redox regulation via S -glutathionylation, i.e., the conjugation of GSH to reactive protein cysteine residues. A number of methodologies that enable quantitative analysis of GSH/GSSG ratio and S-glutathionylated proteins (PSSG), as well as identification and visualization of PSSG in tissue sections or cultured cells are currently available. Here, we have considered the main methodologies applied for GSH, GSSG and PSSG detection in biological samples. This review paper provides an up-to-date critical overview of the application of the most relevant analytical, morphological, and proteomics approaches to detect and analyse GSH, GSSG and PSSG in mammalian samples as well as discusses their current limitations." @default.
- W2743208736 created "2017-08-17" @default.
- W2743208736 creator A5018604525 @default.
- W2743208736 creator A5021170470 @default.
- W2743208736 creator A5021943550 @default.
- W2743208736 creator A5024572384 @default.
- W2743208736 creator A5033177175 @default.
- W2743208736 creator A5046139338 @default.
- W2743208736 creator A5047224202 @default.
- W2743208736 creator A5069021426 @default.
- W2743208736 creator A5078717520 @default.
- W2743208736 creator A5078943926 @default.
- W2743208736 creator A5079055724 @default.
- W2743208736 creator A5091669217 @default.
- W2743208736 date "2017-11-01" @default.
- W2743208736 modified "2023-10-14" @default.
- W2743208736 title "Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells" @default.
- W2743208736 cites W1484633880 @default.
- W2743208736 cites W1487360812 @default.
- W2743208736 cites W1492951734 @default.
- W2743208736 cites W1606524341 @default.
- W2743208736 cites W1699447737 @default.
- W2743208736 cites W1747071827 @default.
- W2743208736 cites W1786714405 @default.
- W2743208736 cites W1836945052 @default.
- W2743208736 cites W1858835589 @default.
- W2743208736 cites W1884362695 @default.
- W2743208736 cites W1892017038 @default.
- W2743208736 cites W1932037753 @default.
- W2743208736 cites W1964774699 @default.
- W2743208736 cites W1964891414 @default.
- W2743208736 cites W1965324668 @default.
- W2743208736 cites W1969101934 @default.
- W2743208736 cites W1970749702 @default.
- W2743208736 cites W1971056974 @default.
- W2743208736 cites W1971306064 @default.
- W2743208736 cites W1976642303 @default.
- W2743208736 cites W1979655239 @default.
- W2743208736 cites W1980729801 @default.
- W2743208736 cites W1980829735 @default.
- W2743208736 cites W1981543241 @default.
- W2743208736 cites W1983685076 @default.
- W2743208736 cites W1986127661 @default.
- W2743208736 cites W1988536671 @default.
- W2743208736 cites W1995823275 @default.
- W2743208736 cites W1996457017 @default.
- W2743208736 cites W1997305410 @default.
- W2743208736 cites W1998246826 @default.
- W2743208736 cites W2005659021 @default.
- W2743208736 cites W2006260865 @default.
- W2743208736 cites W2007064404 @default.
- W2743208736 cites W2008008775 @default.
- W2743208736 cites W2008715208 @default.
- W2743208736 cites W2010478212 @default.
- W2743208736 cites W2010686515 @default.
- W2743208736 cites W2013392029 @default.
- W2743208736 cites W2019299616 @default.
- W2743208736 cites W2019998722 @default.
- W2743208736 cites W2021650429 @default.
- W2743208736 cites W2022502344 @default.
- W2743208736 cites W2023584488 @default.
- W2743208736 cites W2024089744 @default.
- W2743208736 cites W2025038110 @default.
- W2743208736 cites W2028991058 @default.
- W2743208736 cites W2030746296 @default.
- W2743208736 cites W2030969794 @default.
- W2743208736 cites W2031027059 @default.
- W2743208736 cites W2032446075 @default.
- W2743208736 cites W2032609739 @default.
- W2743208736 cites W2034381218 @default.
- W2743208736 cites W2035779406 @default.
- W2743208736 cites W2035995342 @default.
- W2743208736 cites W2037297543 @default.
- W2743208736 cites W2037525789 @default.
- W2743208736 cites W2037776985 @default.
- W2743208736 cites W2041162400 @default.
- W2743208736 cites W2042304493 @default.
- W2743208736 cites W2043008342 @default.
- W2743208736 cites W2043121948 @default.
- W2743208736 cites W2043492633 @default.
- W2743208736 cites W2044754685 @default.
- W2743208736 cites W2044841933 @default.
- W2743208736 cites W2045783623 @default.
- W2743208736 cites W2045914675 @default.
- W2743208736 cites W2046185660 @default.
- W2743208736 cites W2048718653 @default.
- W2743208736 cites W2050610995 @default.
- W2743208736 cites W2054129051 @default.
- W2743208736 cites W2055501861 @default.
- W2743208736 cites W2062927875 @default.
- W2743208736 cites W2063398418 @default.
- W2743208736 cites W2064154241 @default.
- W2743208736 cites W2071765776 @default.
- W2743208736 cites W2071986088 @default.
- W2743208736 cites W2073390777 @default.
- W2743208736 cites W2073446096 @default.
- W2743208736 cites W2073683328 @default.
- W2743208736 cites W2075154209 @default.