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• W2743227965 abstract "Abstract Nicotinic acetylcholine receptors ( nAChR s) are pentameric cation channels expressed in the mammalian CNS , in the peripheral nervous system, and in skeletal muscle. Neuronal‐type nAChR s are also found in several non‐neuronal cell types, including leukocytes. Granulocytes are a subtype of leukocytes that include basophils, eosinophils, and neutrophils. Granulocytes, also known as polymorphonuclear leukocytes, are characterized by their ability to produce, store, and release compounds from intracellular granules. Granulocytes are the most abundant type of leukocyte circulating in the peripheral blood. Granulocyte abundance, nAChR expression, and nAChR upregulation following chronic nicotine administration makes granulocytes interesting models for identifying protein markers of nicotine exposure. Nicotinic receptor subunits and several non‐ nAChR proteins have been identified as protein markers of granulocyte nicotine exposure. We review methods to isolate granulocytes from human tissue, summarize present data about the expression of nAChR s in the three granulocyte cell types (basophils, eosinophils, and neutrophils), describe current knowledge of the effects of nicotine exposure on human granulocyte protein expression, and highlight areas of interest for future investigation. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms . image" @default.
• W2743227965 created "2017-08-17" @default.
• W2743227965 creator A5024286952 @default.
• W2743227965 creator A5040686902 @default.
• W2743227965 date "2017-08-01" @default.
• W2743227965 modified "2023-09-27" @default.
• W2743227965 title "Granulocytes as models for human protein marker identification following nicotine exposure" @default.
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• W2743227965 doi "https://doi.org/10.1111/jnc.14010" @default.
• W2743227965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6057152" @default.
• W2743227965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28791704" @default.
• W2743227965 hasPublicationYear "2017" @default.
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