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- W2743229490 abstract "Endothelial cells (ECs) that line the inner surface of blood vessels are continuously exposed to shear stress induced by blood flow in vivo. It has been thought that the ECs have the mechanism to sense shear stress. Membrane proteins such as a receptor are known to be involved in signal transduction. Thus we thought that there is a relationship between membrane proteins and signal transduction induced by shear stress, and we studied the effect of shear stress on the membrane proteins of the cultured ECs. We visualized the movement of membrane proteins by labeling albumin with fluorescent particles. Before shear stress loading, the particles moved randomly. On the other hand, after shear stress loading, the particles moved in the direction of the downstream region on the cell membrane, and accumulated at the edge of the ECs. The velocity of the movements increased with increasing shear stress." @default.
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- W2743229490 date "2003-01-01" @default.
- W2743229490 modified "2023-10-14" @default.
- W2743229490 title "Movements of Membrane Proteins of Endothelial Cells Under Shear Stress Loading" @default.
- W2743229490 doi "https://doi.org/10.1299/jsmemecjo.2003.5.0_13" @default.
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