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- W2743259091 abstract "Knock-in mice lacking PKN1 kinase activity were generated by introducing a T778A point mutation in the catalytic domain. PKN1[T778A] mutant mice developed to adulthood without apparent external abnormalities, but exhibited lower T and B lymphocyte counts in the peripheral blood than those of wild-type (WT) mice. T and B cell development proceeded in an apparently normal fashion in bone marrow and thymus of PKN1[T778A] mice, however, the number of T and B cell counts were significantly higher in the lymph nodes and spleen of mutant mice in those of WT mice. After transfusion into WT recipients, EGFP-labelled PKN1[T778A] donor lymphocytes were significantly less abundant in the peripheral circulation and more abundant in the spleen and lymph nodes of recipient mice compared with EGFP-labelled WT donor lymphocytes, likely reflecting lymphocyte sequestration in the spleen and lymph nodes in a cell-autonomous fashion. PKN1[T778A] lymphocytes showed significantly lower chemotaxis towards chemokines and sphingosine 1-phosphate (S1P) than WT cells in vitro. The biggest migration defect was observed in response to S1P, which is essential for lymphocyte egress from secondary lymphoid organs. These results reveal a novel role of PKN1 in lymphocyte migration and localization." @default.
- W2743259091 created "2017-08-17" @default.
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- W2743259091 date "2017-08-09" @default.
- W2743259091 modified "2023-09-27" @default.
- W2743259091 title "Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1" @default.
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- W2743259091 doi "https://doi.org/10.1038/s41598-017-07936-9" @default.
- W2743259091 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5550459" @default.
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- W2743259091 hasPublicationYear "2017" @default.
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