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• W2743259618 abstract "Background and Purpose. Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based 18 F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. Materials and Methods. We retrospectively reviewed 27 patients with PMSTs and calculated <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>U</mml:mi><mml:mi mathvariant=normal>V</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>m</mml:mi><mml:mi mathvariant=normal>a</mml:mi><mml:mi mathvariant=normal>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, MTV, and total lesion glycolysis (TLG) to compare their accuracy in predicting progression-free survival (PFS) and overall survival (OS) by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were used to compare the reliability of the metabolic parameters and various clinical factors. Results. MTV exhibited greater accuracy than <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>U</mml:mi><mml:mi mathvariant=normal>V</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>m</mml:mi><mml:mi mathvariant=normal>a</mml:mi><mml:mi mathvariant=normal>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> or TLG. The cut-off values for PFS and OS derived from the AUC data were MTV 45 ml and 83 ml and TLG 250 SUV<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:math>ml and 257 SUV<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:math>ml, respectively. MTV above cut-off value, but not TLG, was identified as significant prognostic factor for PFS by log-lank test (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.04</mml:mn></mml:math>). In addition, MTV was the only significant predictive factors for PFS and OS in the multivariate analysis. Conclusions. MTV was a more accurate predictor of PFS and OS in PMSTs compared to TLG or <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>S</mml:mi><mml:mi mathvariant=normal>U</mml:mi><mml:mi mathvariant=normal>V</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>m</mml:mi><mml:mi mathvariant=normal>a</mml:mi><mml:mi mathvariant=normal>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> and helped decision-making for guiding rational treatment options." @default.
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• W2743259618 date "2017-01-01" @default.
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• W2743259618 title "Metabolic Tumor Volume by ¹⁸F-FDG PET/CT Can Predict the Clinical Outcome of Primary Malignant Spine/Spinal Tumors" @default.
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• W2743259618 doi "https://doi.org/10.1155/2017/8132676" @default.
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