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• W2743269619 abstract "The report presents the results of preclinical study of N-glycoside indolocarbazole derivative LCS-1208 antitumor activity in epidermoid LLC; mechanisms of antitumor action were studied as well. Therapeutic index TI 50 equal to 2.8 was calculated during evaluation of LCS-1208 antitumor selective action on LLC. The assessment of LCS-1208 effect on metastasis in lungs in doses 125 mg/kg and 150 mg/kg shows that the agent is more effective as adjuvant chemotherapy (MGI=45% and 44%, respectively) than neoadjuvant chemotherapy (MGI=33% and 31%, respectively). LCS-1208 had the proved advantage of antitumor effect duration compared to irinotecan: TGI was 95% - 52% and 94% -27%, respectively, for 20 days after completed therapy. Combination of LCS-1208 with irinotecan in half doses of those combined agents (75 mg/kg and 33 mg/kg, respectively) resulted in synergic antitumor effect. Mechanism of antitumor action is determined by LCS-1208 intercalation in the two-stranded DNA and inhibition of topoisomerase I function." @default.
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• W2743269619 date "2015-09-30" @default.
• W2743269619 modified "2023-09-26" @default.
• W2743269619 title "PRECLINICAL STUDY OF ANTITUMOR ACTIVITY OF INDOLOCARBAZOLES N-GLYCOSIDES DERIVATIVE LCS-1208. REPORT II" @default.
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• W2743269619 doi "https://doi.org/10.17650/1726-9784-2015-14-3-41-48" @default.
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