FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743271193> ?p ?o ?g. }

• W2743271193 endingPage "e0182936" @default.
• W2743271193 startingPage "e0182936" @default.
• W2743271193 abstract "T-cell therapy of chronic hepatitis B is a novel approach to restore antiviral T-cell immunity and cure the infection. We aimed at identifying T-cell receptors (TCR) with high functional avidity that have the potential to be used for adoptive T-cell therapy. To this end, we cloned HLA-A*02-restricted, hepatitis B virus (HBV)-specific T cells from patients with acute or resolved HBV infection. We isolated 11 envelope- or core-specific TCRs and evaluated them in comprehensive functional analyses. T cells were genetically modified by retroviral transduction to express HBV-specific TCRs. CD8+ as well as CD4+ T cells became effector T cells recognizing even picomolar concentrations of cognate peptide. TCR-transduced T cells were polyfunctional, secreting the cytokines interferon gamma, tumor necrosis factor alpha and interleukin-2, and effectively killed hepatoma cells replicating HBV. Notably, our collection of HBV-specific TCRs recognized peptides derived from HBV genotypes A, B, C and D presented on different HLA-A*02 subtypes common in areas with high HBV prevalence. When co-cultured with HBV-infected cells, TCR-transduced T cells rapidly reduced viral markers within two days. Our unique set of HBV-specific TCRs with different affinities represents an interesting tool for elucidating mechanisms of TCR-MHC interaction and dissecting specific anti-HBV mechanisms exerted by T cells. TCRs with high functional avidity might be suited to redirect T cells for adoptive T-cell therapy of chronic hepatitis B and HBV-induced hepatocellular carcinoma." @default.
• W2743271193 created "2017-08-17" @default.
• W2743271193 creator A5006731611 @default.
• W2743271193 creator A5023966326 @default.
• W2743271193 creator A5029646740 @default.
• W2743271193 creator A5058992298 @default.
• W2743271193 creator A5061455457 @default.
• W2743271193 creator A5062895290 @default.
• W2743271193 creator A5064332923 @default.
• W2743271193 creator A5068009868 @default.
• W2743271193 creator A5075123441 @default.
• W2743271193 creator A5077773573 @default.
• W2743271193 creator A5085210396 @default.
• W2743271193 creator A5087076959 @default.
• W2743271193 creator A5091762038 @default.
• W2743271193 date "2017-08-08" @default.
• W2743271193 modified "2023-10-03" @default.
• W2743271193 title "Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use" @default.
• W2743271193 cites W1479760379 @default.
• W2743271193 cites W1512812674 @default.
• W2743271193 cites W1579332351 @default.
• W2743271193 cites W1582312891 @default.
• W2743271193 cites W1799137450 @default.
• W2743271193 cites W1937293717 @default.
• W2743271193 cites W1966979298 @default.
• W2743271193 cites W1979781154 @default.
• W2743271193 cites W2001927030 @default.
• W2743271193 cites W2004772469 @default.
• W2743271193 cites W2012392646 @default.
• W2743271193 cites W2020929096 @default.
• W2743271193 cites W2033048068 @default.
• W2743271193 cites W2039437485 @default.
• W2743271193 cites W2043056723 @default.
• W2743271193 cites W2050302632 @default.
• W2743271193 cites W2051173965 @default.
• W2743271193 cites W2056225975 @default.
• W2743271193 cites W2058634008 @default.
• W2743271193 cites W2067963142 @default.
• W2743271193 cites W2068127052 @default.
• W2743271193 cites W2074545819 @default.
• W2743271193 cites W2077200917 @default.
• W2743271193 cites W2080980504 @default.
• W2743271193 cites W2083739796 @default.
• W2743271193 cites W2087055812 @default.
• W2743271193 cites W2091172564 @default.
• W2743271193 cites W2094652659 @default.
• W2743271193 cites W2095353797 @default.
• W2743271193 cites W2098103958 @default.
• W2743271193 cites W2098459535 @default.
• W2743271193 cites W2099468505 @default.
• W2743271193 cites W2100069498 @default.
• W2743271193 cites W2101019626 @default.
• W2743271193 cites W2102428015 @default.
• W2743271193 cites W2105853552 @default.
• W2743271193 cites W2106083290 @default.
• W2743271193 cites W2115356035 @default.
• W2743271193 cites W2120339346 @default.
• W2743271193 cites W2129659050 @default.
• W2743271193 cites W2137046095 @default.
• W2743271193 cites W2138477307 @default.
• W2743271193 cites W2152798078 @default.
• W2743271193 cites W2164439917 @default.
• W2743271193 cites W2219506342 @default.
• W2743271193 cites W2574242476 @default.
• W2743271193 doi "https://doi.org/10.1371/journal.pone.0182936" @default.
• W2743271193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5549754" @default.
• W2743271193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28792537" @default.
• W2743271193 hasPublicationYear "2017" @default.
• W2743271193 type Work @default.
• W2743271193 sameAs 2743271193 @default.
• W2743271193 citedByCount "20" @default.
• W2743271193 countsByYear W27432711932018 @default.
• W2743271193 countsByYear W27432711932019 @default.
• W2743271193 countsByYear W27432711932020 @default.
• W2743271193 countsByYear W27432711932021 @default.
• W2743271193 countsByYear W27432711932022 @default.
• W2743271193 countsByYear W27432711932023 @default.
• W2743271193 crossrefType "journal-article" @default.
• W2743271193 hasAuthorship W2743271193A5006731611 @default.
• W2743271193 hasAuthorship W2743271193A5023966326 @default.
• W2743271193 hasAuthorship W2743271193A5029646740 @default.
• W2743271193 hasAuthorship W2743271193A5058992298 @default.
• W2743271193 hasAuthorship W2743271193A5061455457 @default.
• W2743271193 hasAuthorship W2743271193A5062895290 @default.
• W2743271193 hasAuthorship W2743271193A5064332923 @default.
• W2743271193 hasAuthorship W2743271193A5068009868 @default.
• W2743271193 hasAuthorship W2743271193A5075123441 @default.
• W2743271193 hasAuthorship W2743271193A5077773573 @default.
• W2743271193 hasAuthorship W2743271193A5085210396 @default.
• W2743271193 hasAuthorship W2743271193A5087076959 @default.
• W2743271193 hasAuthorship W2743271193A5091762038 @default.
• W2743271193 hasBestOaLocation W27432711931 @default.
• W2743271193 hasConcept C147483822 @default.
• W2743271193 hasConcept C154317977 @default.
• W2743271193 hasConcept C159047783 @default.
• W2743271193 hasConcept C167672396 @default.
• W2743271193 hasConcept C179223381 @default.
• W2743271193 hasConcept C19317047 @default.

• next