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• W2743273314 startingPage "1629" @default.
• W2743273314 abstract "The use of novel B-cell receptor signaling inhibitors results in high response rates and long progression-free survival in patients with indolent B-cell malignancies, such as chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma and Waldenstrom macroglobulinemia. Ibrutinib, the first-in-class inhibitor of Bruton tyrosine kinase, and idelalisib, the first-in-class inhibitor of phosphatidylinositol 3-kinase δ, have recently been approved for the treatment of several indolent B-cell malignancies. These drugs are especially being used for previously unmet needs, i.e., for patients with relapsed or refractory disease, high-risk cytogenetic or molecular abnormalities, or with comorbidities. Treatment with ibrutinib and idelalisib is generally well tolerated, even by elderly patients. However, the use of these drugs may come with toxicities that are distinct from the side effects of immunochemotherapy. In this review we discuss the most commonly reported and/or most clinically relevant adverse events associated with these B-cell receptor inhibitors, with special emphasis on recommendations for their management." @default.
• W2743273314 created "2017-08-17" @default.
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• W2743273314 creator A5023539212 @default.
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• W2743273314 date "2017-08-03" @default.
• W2743273314 modified "2023-10-12" @default.
• W2743273314 title "Incidence and management of toxicity associated with ibrutinib and idelalisib: a practical approach" @default.
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• W2743273314 doi "https://doi.org/10.3324/haematol.2017.164103" @default.
• W2743273314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5622847" @default.
• W2743273314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28775119" @default.
• W2743273314 hasPublicationYear "2017" @default.
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