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• W2743276286 abstract "Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP, VP35, and VP24, represents an attractive target for drug development; however, the molecular determinants that govern the interactions and functions of these three proteins are still unknown. Through a series of mutational analyses, in combination with biochemical and bioinformatics approaches, we identified a region on VP24 that was critical for its interaction with NP. Importantly, we demonstrated that the interaction between VP24 and NP was required for both nucleocapsid assembly and genome packaging. Not only does this study underscore the critical role that these proteins play in the viral replication cycle, but it also identifies a key interaction interface on VP24 that may serve as a novel target for antiviral therapeutic intervention." @default.
• W2743276286 created "2017-08-17" @default.
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• W2743276286 date "2017-08-09" @default.
• W2743276286 modified "2023-09-27" @default.
• W2743276286 title "Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging" @default.
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• W2743276286 doi "https://doi.org/10.1038/s41598-017-08167-8" @default.
• W2743276286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5550494" @default.
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• W2743276286 hasPublicationYear "2017" @default.
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