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- W2743278622 abstract "Background Genetic research in axSpA is performed in patients with longstanding ankylosing spondylitis (AS). Early axial spondyloarthritis (axSpA) is a diverse patient group in which a minority of the patients have AS. Therefore, it is not known if recently identified genetic risk factors for AS are also risk factors for early axSpA. Objectives To evaluate if ERAP1 and HLA-B*4001 are susceptibility factors for early axSpA. Methods Patients with early axSpA meeting the ASAS classification criteria from the SPACE cohort (inclusion criteria: back pain for ≥3 months, ≤2 years, onset 1 were used as controls. For HLA-B*4001 healthy blood bank donors from the Netherlands (n=5584) and France (n=10177) were used as controls. Results In 486 DESIR patients (mean age 32.5 (SD 8.6); 50% male; 84% HLA-B27+; 18% X-SI+) and 144 SPACE patients (mean age 29.5 (SD 8); 51% male; 88% HLA-B27+; 24% X-SI+) ERAP1 SNP rs30187 was more common than in controls (OR 1.2, p=0.01 in meta-analysis; table 1). rs17482078 and rs10050860 were negatively associated with early axSpA (both 0.7 (0.6–0.9) p Conclusions ERAP1 rs30187 is a genetic risk factor for early axSpA. To our knowledge this is the first report of genetic risk factor research in early axSpA patients meeting the ASAS criteria. Larger cohorts are needed to study additional AS risk factors. References Kadi A, Izac B, Said-Nahal R, Leboime A, Van Praet L, de Vlam K, et al. Investigating the genetic association between ERAP1 and spondyloarthritis. Ann Rheum Dis. 2013;72(4):608–13. Disclosure of Interest None declared" @default.
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- W2743278622 date "2017-06-01" @default.
- W2743278622 modified "2023-10-17" @default.
- W2743278622 title "OP0241 Erap1 is a susceptibility factor for early axial spondyloarthritis meeting the asas classification criteria: results from the desir and space cohorts" @default.
- W2743278622 doi "https://doi.org/10.1136/annrheumdis-2017-eular.5955" @default.
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