FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743281671> ?p ?o ?g. }

• W2743281671 endingPage "74538" @default.
• W2743281671 startingPage "74527" @default.
• W2743281671 abstract "// Xiaoli Dong 1, 7, 8, * , Jiaxiao Zhang 2, * , Zhilin Zhou 3, * , Zhennan Ye 4 , Jiahao Chen 2 , Jifan Yuan 2 , Fengjun Cao 5 , Xuanbin Wang 5, 6 , Wenchao Liu 1 , Wenxuan Yu 1, 7 and Xiaohua Li 1, 2 1 The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PRC 2 Department of Research and Development, Shenzhen Benevop Biomedical Co., Ltd, Shenzhen, PRC 3 Department of General Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PRC 4 Department of Biochemistry II, Jena University Hospital, Jena, Germany 5 Laboratory of Chinese Herbal Pharmacology, Oncology Center, Renmin Hospital, Hubei University of Medicine, Shiyan, PRC 6 Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Shiyan, PRC 7 Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PRC 8 State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen, PRC * These authors have contributed equally to this work Correspondence to: Xiaohua Li, email: lixiaohua@benevop.com Keywords: maslinic acid, autophagy, regulation, Beclin1, Bcl2 Received: March 22, 2017      Accepted: June 24, 2017      Published: August 05, 2017 ABSTRACT Maslinic acid (2α, 3β-dihydroxyolean-12-en-28-oic acid, MA) was isolated from natural plants and showed anti-cancer activity in rat Pheochromocytoma PC12 cells in our previous studies. We now discover that MA disrupts the interaction between Bcl2 and autophagy scaffold protein Beclin1 in the above cell line, leading to the up-regulation of autophagy. We investigated the effect of MA on the interaction between Bcl2 and Beclin1 by biochemical and biophysical methods in combination with autophagy characterization in the above cell line. Our results suggest that MA may serve as an autophagy activator by directly blocking the Bcl2-Beclin1 interaction to release free Beclin1 required for the recruitment of autophagy positive regulators, implying MA may exert its anti-cancer activity by regulating autophagy." @default.
• W2743281671 created "2017-08-17" @default.
• W2743281671 creator A5011354166 @default.
• W2743281671 creator A5020066445 @default.
• W2743281671 creator A5039129882 @default.
• W2743281671 creator A5060220713 @default.
• W2743281671 creator A5060756283 @default.
• W2743281671 creator A5066744318 @default.
• W2743281671 creator A5071814939 @default.
• W2743281671 creator A5072071140 @default.
• W2743281671 creator A5075987464 @default.
• W2743281671 creator A5085645609 @default.
• W2743281671 creator A5089285560 @default.
• W2743281671 date "2017-08-05" @default.
• W2743281671 modified "2023-10-06" @default.
• W2743281671 title "Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells" @default.
• W2743281671 cites W1765573197 @default.
• W2743281671 cites W1806289054 @default.
• W2743281671 cites W1964322868 @default.
• W2743281671 cites W1965611547 @default.
• W2743281671 cites W1977767269 @default.
• W2743281671 cites W1980245591 @default.
• W2743281671 cites W1988110756 @default.
• W2743281671 cites W1991903498 @default.
• W2743281671 cites W1996359625 @default.
• W2743281671 cites W2001591494 @default.
• W2743281671 cites W2012070337 @default.
• W2743281671 cites W2030720740 @default.
• W2743281671 cites W2031169909 @default.
• W2743281671 cites W2038091455 @default.
• W2743281671 cites W2055782852 @default.
• W2743281671 cites W2059738518 @default.
• W2743281671 cites W2062979344 @default.
• W2743281671 cites W2064034023 @default.
• W2743281671 cites W2065306690 @default.
• W2743281671 cites W2073223702 @default.
• W2743281671 cites W2085470568 @default.
• W2743281671 cites W2096308078 @default.
• W2743281671 cites W2099347347 @default.
• W2743281671 cites W2106450152 @default.
• W2743281671 cites W2118138635 @default.
• W2743281671 cites W2119385480 @default.
• W2743281671 cites W2120242368 @default.
• W2743281671 cites W2124105006 @default.
• W2743281671 cites W2124186983 @default.
• W2743281671 cites W2138780264 @default.
• W2743281671 cites W2143973810 @default.
• W2743281671 cites W2153825616 @default.
• W2743281671 cites W2157002874 @default.
• W2743281671 cites W2164337950 @default.
• W2743281671 cites W2169071211 @default.
• W2743281671 cites W2232753833 @default.
• W2743281671 cites W2332228999 @default.
• W2743281671 cites W2339110476 @default.
• W2743281671 cites W2416007164 @default.
• W2743281671 cites W2466257097 @default.
• W2743281671 cites W2493170880 @default.
• W2743281671 cites W2502907583 @default.
• W2743281671 cites W2512993972 @default.
• W2743281671 cites W2560700738 @default.
• W2743281671 cites W2738996050 @default.
• W2743281671 cites W2743254891 @default.
• W2743281671 doi "https://doi.org/10.18632/oncotarget.20210" @default.
• W2743281671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5650360" @default.
• W2743281671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29088805" @default.
• W2743281671 hasPublicationYear "2017" @default.
• W2743281671 type Work @default.
• W2743281671 sameAs 2743281671 @default.
• W2743281671 citedByCount "13" @default.
• W2743281671 countsByYear W27432816712018 @default.
• W2743281671 countsByYear W27432816712019 @default.
• W2743281671 countsByYear W27432816712020 @default.
• W2743281671 countsByYear W27432816712021 @default.
• W2743281671 countsByYear W27432816712022 @default.
• W2743281671 countsByYear W27432816712023 @default.
• W2743281671 crossrefType "journal-article" @default.
• W2743281671 hasAuthorship W2743281671A5011354166 @default.
• W2743281671 hasAuthorship W2743281671A5020066445 @default.
• W2743281671 hasAuthorship W2743281671A5039129882 @default.
• W2743281671 hasAuthorship W2743281671A5060220713 @default.
• W2743281671 hasAuthorship W2743281671A5060756283 @default.
• W2743281671 hasAuthorship W2743281671A5066744318 @default.
• W2743281671 hasAuthorship W2743281671A5071814939 @default.
• W2743281671 hasAuthorship W2743281671A5072071140 @default.
• W2743281671 hasAuthorship W2743281671A5075987464 @default.
• W2743281671 hasAuthorship W2743281671A5085645609 @default.
• W2743281671 hasAuthorship W2743281671A5089285560 @default.
• W2743281671 hasBestOaLocation W27432816711 @default.
• W2743281671 hasConcept C142724271 @default.
• W2743281671 hasConcept C185592680 @default.
• W2743281671 hasConcept C188947578 @default.
• W2743281671 hasConcept C190283241 @default.
• W2743281671 hasConcept C203522944 @default.
• W2743281671 hasConcept C204787440 @default.
• W2743281671 hasConcept C55493867 @default.
• W2743281671 hasConcept C556039675 @default.
• W2743281671 hasConcept C71924100 @default.
• W2743281671 hasConcept C98274493 @default.

• next