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- W2743282746 abstract "A molecular biology-based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant prognostic and predictive biomarkers and stratified PPGLs into three main clusters. Each subgroup has a distinct molecular-biochemical-imaging signature. Concurrently, new methods for biochemical analysis, functional imaging, and medical therapies have also become available. The research community now strives to match the cluster biomarkers with the best intervention. The concept of precision medicine has been long awaited and holds great promise for improved care. Here, we review the current and future PPGL classifications, with a focus on hereditary syndromes. We discuss the current strengths and shortcomings of precision medicine and suggest a condensed manual for diagnosis and treatment of both adult and pediatric patients with PPGL. Finally, we consider the future direction of this field, with a particular focus on how advanced molecular characterization of PPGL can improve a patient's outcome, including cures and, ultimately, disease prevention." @default.
- W2743282746 created "2017-08-17" @default.
- W2743282746 creator A5012903150 @default.
- W2743282746 creator A5013015930 @default.
- W2743282746 creator A5028135050 @default.
- W2743282746 date "2017-08-04" @default.
- W2743282746 modified "2023-10-18" @default.
- W2743282746 title "New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification" @default.
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